ArticleNature chemistry2016
Oriented electric fields as future smart reagents in chemistry.
Article in Nature chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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Who cites it
127 citing papers in PubMed.
- Towards next generation enzyme mimics through local electric field control in organic cage catalysts.Chemical science · 2026Article
- Biomolecular condensates can function as inherent catalysts.Molecular cell · 2026Article
- Electrostatic Engineering of Phosphoketolase Enhances Activity on Small Nonphosphorylated Sugars and Improves Cell-Free ATP Regeneration from Inexpensive C2-Substrates.The journal of physical chemistry. B · 2026Article
- Analytic Nuclear Gradients Including Oriented External Electric Fields in a Molecule-Fixed Frame.Journal of chemical theory and computation · 2026Article
- Acid-Catalyzed Rearrangement Reaction for Single-Molecule Junction Formation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Biomolecular condensates mediate C-N bond formation.Nature chemical biology · 2026Article
- Effect of Salt Additives on Dinitrogen Activation Mediated by Boron-Based Compounds: Insights from Theory.Inorganic chemistry · 2026Article
- A Nonenzymatic Analogue of the Biosynthesis of Pyridoxal Vitamers.Journal of the American Chemical Society · 2026Article
- Article
- Electric Field Effects on Amine Regeneration in Post-Combustion Carbon Capture-Part I: Static Electric Fields as a Reference Mechanistic Baseline.Molecules (Basel, Switzerland) · 2026Article
- Dark Reactions in Microdroplets Explain Widespread Artifacts in Metabolomic Profiling.ACS measurement science au · 2026Article
- Origins of the Intrinsic Redox Activity of Biomolecular Condensates.Journal of the American Chemical Society · 2026Article
- Probing a Reactive Alkyne Center Aligned via a Triphenylmethane Tripod on Au(111) for Electric Field-Induced Chemistry by STM and TERS.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Halogen Bonds under Electric Field with Quantum Accuracy and Relativistic Basis Sets.The journal of physical chemistry. A · 2026Article
- Disrupting the Photochemical Landscape of a β-Diketone via Electrostatic Perturbation of Ground-State Tautomers.Journal of the American Chemical Society · 2025Article
- Entropy Governs the Structure and Reactivity of Water Dissociation Under Electric Fields.Journal of the American Chemical Society · 2025Article
- Exploring Molecular Equilibrium Geometries in Static and Quantized Fields.Journal of chemical theory and computation · 2025Article
- Oriented Electric Fields─Universal Catalysts.Accounts of chemical research · 2025Article
- Computational Electrosynthesis: A Perspective on Mechanistic Questions, Methodological Approaches, and Elucidating the Role of the Electrical Double Layer.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025Review
- Anion-π interaction-induced phase separation as a prebiotic pathway to oxygenation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
67 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oriented external electric fields (OEEFs) as 'smart reagents' are no longer a theoretical dream. Here, we discuss the wide-ranging potential of using OEEFs to catalyse and control a variety of non-redox reactions and impart selectivity at will. An OEEF along the direction of electron reorganization (the so-called reaction axis) will catalyse nonpolar reactions by orders of magnitude, control regioselectivity and induce spin-state selectivity. Simply flipping the direction of the OEEF or orienting it off of the reaction axis, will control at will the endo/exo ratio in Diels-Alder reactions and steps in enzymatic cycles. This Perspective highlights these outcomes using theoretical results for hydrogen abstraction reactions, epoxidation of double bonds, C-C bond forming reactions, proton transfers and the cycle of the enzyme cytochrome P450, as well as recent experimental data. We postulate that, as experimental techniques mature, chemical syntheses may become an exercise in zapping oriented molecules with OEEFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.