Evidence map›Paper›PMID 27874848›Full record

ReviewTranslational psychiatry2016

The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders.

A Cattaneo, N Cattane, V Begni, C M Pariante, M A Riva

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 9 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 9 syntheses or guidelines pooled it, 231 citations in OpenAlex.

  1. Pooled it
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  5. TheBrain plasticity (Amsterdam, Netherlands) · 2022
    Pooled it
  6. Evaluation of the Relationship BetweenFrontiers in psychiatry · 2022
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  17. Neurological Effects ofNutrients · 2026
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

A CattaneoBiological Psychiatry Unit, IRCCS Fatebenefratelli San Giovanni di Dio, Brescia, Italy.
N CattaneBiological Psychiatry Unit, IRCCS Fatebenefratelli San Giovanni di Dio, Brescia, Italy.
V BegniDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
C M ParianteDepartment of Psychological Medicine, Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, King's College London, London, UK.
M A RivaDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
King's College London · GBUniversity of Milan · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

Medical Research Council G108/603
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, and influences synaptic efficiency and plasticity. The human BDNF gene consists of 11 exons, and distinct BDNF transcripts are produced through the use of alternative promoters and splicing events. The majority of the BDNF transcripts can be detected not only in the brain but also in the blood cells, although no study has yet investigated the differential expression of BDNF transcripts at the peripheral level. This review provides a description of the human BDNF gene structure as well as a summary of clinical and preclinical evidence supporting the role of BDNF in the pathogenesis of psychiatric disorders. We will discuss several mechanisms as possibly underlying BDNF modulation, including epigenetic mechanisms. We will also discuss the potential use of peripheral BDNF as a biomarker for psychiatric disorders, focusing on the factors that can influence BDNF gene expression and protein levels. Within this context, we have also characterized, for we believe the first time, the expression of BDNF transcripts in the blood, with the aim to provide novel insights into the molecular mechanisms and signaling that may regulate peripheral BDNF gene expression levels.

Indexed as

AnimalsBrainEpigenesis, GeneticGene Expression RegulationGenetic MarkersHumansMental DisordersReference ValuesTranscription, GeneticGenetic Markers

Identifiers

PMID27874848
PMCPMC5314126
OpenAlexW2549902875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.