ArticleeLife2016
Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed.
- Article
- Assembled and annotated reference genome and demographic history of the eastern chipmunk (Tamias striatus).Molecular genetics and genomics : MGG · 2026Article
- Article
- Dermal fibroblast cultures recapitulate differences between deermice and mice in responses to a Toll-like receptor agonist.bioRxiv : the preprint server for biology · 2025Article
- The DREAM complex links somatic mutation, lifespan, and disease.bioRxiv : the preprint server for biology · 2025Article
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines.Cells · 2025Article
- Among-population variation in telomere regulatory proteins and their potential role as hidden drivers of intraspecific variation in life history.The Journal of animal ecology · 2025Article
- Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist.Frontiers in immunology · 2025Article
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.Cell reports · 2024Article
- Primary Cell Culture as a Model System for Evolutionary Molecular Physiology.International journal of molecular sciences · 2024Review
- Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors.Communications chemistry · 2024Article
- The dual role of the DREAM/G2M pathway in non-tumorigenic immortalization of senescent cells.FEBS open bio · 2024Article
- High-content phenotypic analysis ofbioRxiv : the preprint server for biology · 2024Article
- GTax: improving de novo transcriptome assembly by removing foreign RNA contamination.Genome biology · 2024Article
- GDF11 and aging biology - controversies resolved and pending.The journal of cardiovascular aging · 2023Article
- Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals.The EMBO journal · 2023Article
- The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging.Neuroscience and biobehavioral reviews · 2023Review
- Principles of metabolome conservation in animals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and maintained under identical cell culture conditions. We developed a pipeline for obtaining species-specific ortholog sequences, profiled gene expression by RNA-seq and small molecules by metabolite profiling, and identified genes and metabolites correlating with species longevity. Cells from longer lived species up-regulated genes involved in DNA repair and glucose metabolism, down-regulated proteolysis and protein transport, and showed high levels of amino acids but low levels of lysophosphatidylcholine and lysophosphatidylethanolamine. The amino acid patterns were recapitulated by further analyses of primate and bird fibroblasts. The study suggests that fibroblast profiling captures differences in longevity across mammals at the level of global gene expression and metabolite levels and reveals pathways that define these differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.