ArticleeLife2016
SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 52 citations in OpenAlex.
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- Identification of a neural basis for anorexia nervosa.bioRxiv : the preprint server for biology · 2026Article
- Dietary energy levels regulate feed intake of broilers through the brain-gut axis.Frontiers in veterinary science · 2026Article
- Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.Nature communications · 2025Article
- High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation via Central Fibroblast Growth Factor Receptor Signaling.Circulation · 2025Article
- Development and characterization of an Sf-1-Flp mouse model.JCI insight · 2025Article
- Development and Characterization of abioRxiv : the preprint server for biology · 2025Article
- Hypothalamic neural circuits regulating energy expenditure.Vitamins and hormones · 2025Review
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- LCoRL Regulates Growth and Metabolism.Endocrinology · 2024Article
- Chemogenetic Excitation of Ventromedial Hypothalamic Steroidogenic Factor 1 (SF1) Neurons Increases Muscle Thermogenesis in Mice.Biomolecules · 2024Article
- ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis.Diabetologia · 2024Article
- Steroidogenic Factor-1 form and function: From phospholipids to physiology.Advances in biological regulation · 2024Review
- Ghrelin-responsive mediobasal hypothalamic neurons mediate exercise-associated food intake and exercise endurance.JCI insight · 2023Article
- SF-1 Induces Nuclear PIP2.Biomolecules · 2023Article
- Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism.Molecular metabolism · 2023Review
- Obesity: an evolutionary context.Life metabolism · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1α expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.