ArticleAutism research : official journal of the International Society for Autism Research2017
Prenatal toxoplasmosis antibody and childhood autism.
Article in Autism research : official journal of the International Society for Autism Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Seroprevalence of Toxoplasma gondii infection among patients with psychiatric and neurologic disorders in Türkiye: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- Association between human herpesviruses infections and childhood neurodevelopmental disorders: insights from two-sample mendelian randomization analyses and systematic review with meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Toxoplasma gondii infection and testosterone alteration: A systematic review and meta-analyses.PloS one · 2024Pooled it
- Blockade of Tim-3 pathway in a mouse model of Toxoplasmosis: impact on brain leukocyte infiltration, parasite burden, and neuroinflammation.Scientific reports · 2026Article
- Prebiotic Treatment During Pregnancy Prevents Social Deficits Associated with Autism Spectrum Disorder-like Behavior Induced by Maternal Immune Activation.Microorganisms · 2025Article
- Possible association between Toxoplasma gondii infection and autism spectrum disorder.Parasites, hosts and diseases · 2025Review
- A Hidden Mark of a Troubled Past: Neuroimaging and Transcriptomic Analyses Reveal Interactive Effects of Maternal Immune Activation and Adolescent THC Exposure Suggestive of Increased Neuropsychiatric Risk.Biological psychiatry global open science · 2025Article
- Exploring the potential association between dietary factors and autism spectrum disorder: a Mendelian randomization analysis and retrospective study.Frontiers in nutrition · 2025Article
- Elevated matrix Metalloproteinase-9 associated with reduced cerebellar perineuronal nets in female mice with toxoplasmosis.Brain, behavior, & immunity - health · 2024Article
- Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children.Parasitology research · 2023Article
- Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway.Journal of ginseng research · 2022Article
- Gene Regulation Analysis Reveals Perturbations of Autism Spectrum Disorder during Neural System Development.Genes · 2021Article
- Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies.BMC pediatrics · 2021Article
- Unravelling Toxoplasma treatment: conventional drugs toward nanomedicine.World journal of microbiology & biotechnology · 2021Review
- Infections, inflammation, and risk of neuropsychiatric disorders: the neglected role of "co-infection".Heliyon · 2020Review
- Neurological Findings in Children without Congenital Microcephaly Exposed to Zika Virus in Utero: A Case Series Study.Viruses · 2020Article
- Transcriptomic Analysis Reveals Abnormal Expression of Prion Disease Gene Pathway in Brains from Patients with Autism Spectrum Disorders.Brain sciences · 2020Article
- Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease.International journal of molecular sciences · 2020Review
- Predictors ofInternational journal of pediatrics · 2020Article
- Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
There is evidence that some maternal infections during the prenatal period are associated with neurodevelopmental disorders, such as childhood autism. However, the association between autism and Toxoplasma gondii (T. gondii), an intracellular parasite, remains unclear. The authors examined whether serologically confirmed maternal antibodies to T. gondii are associated with odds of childhood autism in offspring. The study is based on a nested case-control design of a large national birth cohort (N = 1.2 million) and the national psychiatric registries in Finland. There were 874 cases of childhood autism and controls matched 1:1 on date of birth, sex, birthplace and residence in Finland. Maternal sera were prospectively assayed from a national biobank for T. gondii IgM and IgG antibodies; IgG avidity analyses were also performed. High maternal T. gondii IgM antibody was associated with a significantly decreased odds of childhood autism. Low maternal T. gondii IgG antibody was associated with increased offspring odds of autism. In women with high T. gondii IgM antibodies, the IgG avidity was high for both cases and controls, with the exception of three controls. The findings suggest that the relationship between maternal T. gondii antibodies and odds of childhood autism may be related to the immune response to this pathogen or the overall activation of the immune system. Autism Res 2017, 10: 769-777. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.