Evidence map›Paper›PMID 27874264›Full record

ReviewJournal of biophotonics2016

Photobiomodulation in human muscle tissue: an advantage in sports performance?

Cleber Ferraresi, Ying-Ying Huang, Michael R Hamblin

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of biophotonics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 75 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03225976 nacompletednot on this mapstarted 2018, after this paper: background citation

Effect of Light-Emitting Diode on the Strenght and Resistence Capacities of Cycling Athletes

TypeinterventionalSponsorUniversity of Sao PauloRan2018 to 2019Enrolled48ConditionsAthletesArmsLight-Emitting Diode Device, Sham Light-Emitting Diode Device
NCT04445545 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of High Intensity Laser Therapy (HILT) and Stretching Exercises on Cervical Flexibility and Pain Reduction in Myofascial Trigger Points. Randomized Clinical Trial (RCT).

TypeinterventionalSponsorQuiropraxia y EquilibrioRan2025 to 2025Enrolled24ConditionsMyofascial Trigger Point Pain (MTrP)ArmsHigh intensity laser therapy (HILT), Therapeutic Ultrasound (US), Stretching exercise
NCT05344222 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Photobiomodulation Conditioning of Orofacial Tissue in Surgery for Removal of Impacted Mandibular Third Molars: Randomized, Sham-controlled, Double-blind Clinical Trial

TypeinterventionalSponsorUniversity of Nove de JulhoRan2021 to 2022Enrolled62ConditionsImpacted Third Molar ToothArmsInfrared LED, Similar device - Infrared ED
NCT07224646 narecruitingnot on this mapstarted 2025, after this paper: background citation

Whole-Body Photobiomodulation Use in Professional Soccer Players During a State Championship

TypeinterventionalSponsorUniversidade Federal de Sao CarlosRan2025 to 2026Enrolled24ConditionsAthletic Performance, Muscle Fatigue, Muscle Strength, SportsArmsWhole-Body Photobiomodulation (PBM) (Active PBM), Sham PBM
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Transabdominal photobiomodulation applications: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cleber FerraresiWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ying-Ying HuangWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Photobiomodulation (PBM) describes the use of red or near-infrared (NIR) light to stimulate, heal, and regenerate damaged tissue. Both preconditioning (light delivered to muscles before exercise) and PBM applied after exercise can increase sports performance in athletes. This review covers the effects of PBM on human muscle tissue in clinical trials in volunteers related to sports performance and in athletes. The parameters used were categorized into those with positive effects or no effects on muscle performance and recovery. Randomized controlled trials and case-control studies in both healthy trained and untrained participants, and elite athletes were retrieved from MEDLINE up to 2016. Performance metrics included fatigue, number of repetitions, torque, hypertrophy; measures of muscle damage and recovery such as creatine kinase and delayed onset muscle soreness. Searches retrieved 533 studies, of which 46 were included in the review (n = 1045 participants). Studies used single laser probes, cluster of laser diodes, LED clusters, mixed clusters (lasers and LEDs), and flexible LED arrays. Both red, NIR, and red/NIR mixtures were used. PBM can increase muscle mass gained after training, and decrease inflammation and oxidative stress in muscle biopsies. We raise the question of whether PBM should be permitted in athletic competition by international regulatory authorities.

Indexed as

Athletic PerformanceLow-Level Light TherapyAthletesDouble-Blind MethodHumansInflammationMuscle FatigueMuscle, SkeletalOxidative StressRandomized Controlled Trials as Topiccreatine kinasedelayed onset muscle sorenessfatigueLEDTLLLTphotobiomodulation

Identifiers

PMID27874264
PMCPMC5167494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.