Evidence map›Paper›PMID 27874106›Full record

SynthesisIranian biomedical journal2017

Is Leukocyte Telomere Length Related with Lung Cancer Risk?: A Meta-Analysis.

Behrooz Karimi, Masud Yunesian, Ramin Nabizadeh, Parvin Mehdipour, Afsaneh Aghaie

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Iranian biomedical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  10. Genetic variations inOncotarget · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Behrooz KarimiDepartment of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Enghelab St., Tehran, Iran.
Masud YunesianDepartment of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Enghelab St., Tehran, Iran.
Ramin NabizadehDepartment of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Enghelab St., Tehran, Iran.
Parvin MehdipourDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Enghelab St., Tehran, Iran.
Afsaneh AghaieHigh Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Tehran University of Medical Sciences · IRHigh Institute for Education and Research in Transfusion Medicine · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard. The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique.

methodsA systematic search was carried out using PubMed, EMBASE, and ISI before 2015. A total of 2925 cases of lung cancer and 2931 controls from 9 studies were employed to probe the relationship between lung cancer and telomere length .ORs were used at 95% CI. Random-effects models were used to investigate this relationship based on the heterogeneity test. Heterogeneity among studies was analyzed employing subgroup analysis based on type studies and the year of publication.

resultsRandom-effects meta-analysis revealed that patients with lung cancer were expected to have shorter telomere length than the control (1.13, 95% CI: 0.82-1.81, P=0.46). The summary of the pooled ORs of telomere length in adenocarcinoma lung cancer patients was 1 (95%CI=0.68-1.47, I2=93%) compared to patients with squamous cell lung cancer, which was 1.78 (95% CI=1.25-2.53, I2=3.9%). The meta-regression revealed that the effect of telomere length shortening, decreased and increased with the year of publication and the age of risks to lung cancer, was clearly related to short telomeres lengths.

conclusionLung cancer risks clearly related with short telomeres lengths. In patients with breathing problems, lung cancer risk can be predicted by telomere length adjustment with age, sex, and smoking.

Indexed as

Telomere HomeostasisHumansLeukocytesLung NeoplasmsPublication BiasRisk FactorsSensitivity and SpecificitySmokingLung cancerMeta-analysisTelomere length

Identifiers

PMID27874106
PMCPMC5392217
OpenAlexW2551370971

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.