Evidence map›Paper›PMID 27874074›Full record

Observational studyScientific reports2016

Second-trimester urine nephrin:creatinine ratio versus soluble fms-like tyrosine kinase-1:placental growth factor ratio for prediction of preeclampsia among asymptomatic women.

Tianyue Zhai, Itsuko Furuta, Kinuko Nakagawa, Takashi Kojima, Takeshi Umazume, Satoshi Ishikawa, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami

Open access · goldAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Clinical significance of severe proteinuria in preeclampsia: a multicenter study of maternal and neonatal outcomes.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  3. Urinary Nephrin Concentrations in Preeclampsia (with and without Complications) vs Normal Pregnancies.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tianyue ZhaiDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Itsuko FurutaDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Kinuko NakagawaDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Takashi KojimaDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Takeshi UmazumeDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Satoshi IshikawaDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Takahiro YamadaDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Mamoru MorikawaDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Hisanori MinakamiDepartment of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Hokkaido University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective observational study compare urine nephrin:creatinine ratio (NCR, ng/mg) with serum soluble fms-like tyrosine kinase-1:placental growth factor ratio (FPR, pg/pg) for preeclampsia (PE) prediction among unselected asymptomatic pregnant women in 2

Indexed as

AdultCreatinineDemographyFemaleHumansHypertensionMass ScreeningMembrane ProteinsMiddle AgedPlacenta Growth FactorPre-EclampsiaPregnancyPregnancy Trimester, SecondProteinuriaSolubilityVascular Endothelial Growth Factor Receptor-1CreatinineMembrane ProteinsnephrinPGF protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID27874074
PMCPMC5118691
OpenAlexW2549849252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.