ArticleScientific reports2016
An ancient role for nitric oxide in regulating the animal pelagobenthic life cycle: evidence from a marine sponge.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- Metagenomic insights into mechanisms of coral larval settlement induction and inhibition by marine biofilms.Environmental microbiome · 2026Article
- Prioritising research on endocrine disruption in the marine environment: a global perspective.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Early transcription factor activation distinguishes symbiotic from non-symbiotic bacteria during microbiome processing in a sponge.The ISME journal · 2026Article
- Aboral cell types ofScience advances · 2025Article
- Culture-supported ecophysiology of the SAR116 clade demonstrates metabolic and spatial niche partitioning.The ISME journal · 2025Article
- Genome-scale metabolic modelling reveals interactions and key roles of symbiont clades in a sponge holobiont.Nature communications · 2024Article
- The Buds of Oscarella lobularis (Porifera, Homoscleromorpha): A New Convenient Model for Sponge Cell and Evolutionary Developmental Biology.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Co-occurring nitrifying symbiont lineages are vertically inherited and widespread in marine sponges.The ISME journal · 2024Article
- Multiomics integration for the function of bacterial outer membrane vesicles in the larval settlement of marine sponges.Frontiers in microbiology · 2024Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
- Taurine as a key intermediate for host-symbiont interaction in the tropical sponge Ianthella basta.The ISME journal · 2023Article
- Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates.International journal of molecular sciences · 2023Review
- TRPM7-Mediated CaInternational journal of molecular sciences · 2023Article
- Article
- Nitric oxide signaling in ctenophores.Frontiers in neuroscience · 2023Article
- Potential for host-symbiont communication via neurotransmitters and neuromodulators in an aneural animal, the marine spongeFrontiers in neural circuits · 2023Article
- Gene activation of metazoan Fox transcription factors at the onset of metamorphosis in the marine demosponge Amphimedon queenslandica.Development, growth & differentiation · 2022Article
- Microbes from Mum: symbiont transmission in the tropical reef sponge Ianthella basta.ISME communications · 2022Article
- Molecular and cellular architecture of the larval sensory organ in the cnidarian Nematostella vectensis.Development (Cambridge, England) · 2022Article
- Phototransduction in a marine sponge provides insights into the origin of animal vision.iScience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many marine invertebrates, larval metamorphosis is induced by environmental cues that activate sensory receptors and signalling pathways. Nitric oxide (NO) is a gaseous signalling molecule that regulates metamorphosis in diverse bilaterians. In most cases NO inhibits or represses this process, although it functions as an activator in some species. Here we demonstrate that NO positively regulates metamorphosis in the poriferan Amphimedon queenslandica. High rates of A. queenslandica metamorphosis normally induced by a coralline alga are inhibited by an inhibitor of nitric oxide synthase (NOS) and by a NO scavenger. Consistent with this, an artificial donor of NO induces metamorphosis even in the absence of the alga. Inhibition of the ERK signalling pathway prevents metamorphosis in concert with, or downstream of, NO signalling; a NO donor cannot override the ERK inhibitor. NOS gene expression is activated late in embryogenesis and in larvae, and is enriched in specific epithelial and subepithelial cell types, including a putative sensory cell, the globular cell; DAF-FM staining supports these cells being primary sources of NO. Together, these results are consistent with NO playing an activating role in induction of A. queenslandica metamorphosis, evidence of its highly conserved regulatory role in metamorphosis throughout the Metazoa.
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