ArticleScientific reports2016
Waterborne aripiprazole blunts the stress response in zebrafish.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Direct photolysis of tiapride in water: deep insights into desulfonation reaction.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Development of an HPLC-HRMS Method for the Identification and Semi-Quantitation in River Water Samples of the Transformation Products Originated From Heterogeneous Photocatalysis of Antipsychotic Drugs.Journal of separation science · 2025Article
- Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Review
- Effect of levodopa/carbidopa on stress response in zebrafish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Article
- Salivary cortisol response to psychosocial stress in patients with first-episode psychosis.Croatian medical journal · 2021Article
- Waterborne agrichemicals compromise the anti-predatory behavior of zebrafish.Environmental science and pollution research international · 2020Article
- 17-α-Ethinylestradiol modulates endocrine and behavioral responses to stress in zebrafish.Environmental science and pollution research international · 2020Article
- Effects of N-acetylcysteine amide on anxiety and stress behavior in zebrafish.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Feeding regimen modulates zebrafish behavior.PeerJ · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.
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Registered trials
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