Evidence map›Paper›PMID 27874037›Full record

ArticleScientific reports2016

Visualizing epithelial expression of EGFR in vivo with distal scanning side-viewing confocal endomicroscope.

Xiyu Duan, Haijun Li, Juan Zhou, Quan Zhou, Kenn R Oldham, Thomas D Wang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. In Vivo Microendoscopy in the Near-Infrared II Window.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Review
  3. Integrating Optics and Parametrically-Resonant Micro-Scanner Design for Large Working Distance Implantable Microscopy.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Motion Estimation for a Compact Electrostatic Microscanner via Shared Driving and Sensing Electrodes in Endomicroscopy.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2020
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiyu DuanDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Haijun LiDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Juan ZhouDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Quan ZhouDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Kenn R OldhamDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Thomas D WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
University of Michigan–Ann Arbor · US

Funding

Multiplexed imaging of biliary intra-epithelial neoplasiaR01CA200007 · NCI · UNIVERSITY OF WASHINGTON · PI SEIBEL, ERIC J, WANG, THOMAS D · 2015 to 2019
$2.9M
Early Detection of Colorectal Cancer on Near-Infrared Molecular EndoscopyR01CA193377 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2016 to 2020
$2.1M
Multi-Photon endomicroscope for real-time in vivo vertical sectioningR01EB020644 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLDHAM, KENN R · 2015 to 2018
$1.3M
NCI NIH HHS R01 CA193377NCI NIH HHS R01 CA200007NIBIB NIH HHS R01 EB020644
6 · The paper itself

Abstract

Confocal endomicroscopy is an emerging imaging technology that has recently been introduced into the clinic to instantaneously collect "optical biopsies" in vivo with histology-like quality. Here, we demonstrate a fast scanner located in the distal end of a side-viewing instrument using a compact lens assembly with numerical aperture of 0.5 to achieve a working distance of 100 μm and field-of-view of 300 × 400 μm

Indexed as

AnimalsCarbocyaninesEndoscopy, GastrointestinalErbB ReceptorsIntestinal MucosaMiceMicro-Electrical-Mechanical SystemsMicroscopy, ConfocalReproducibility of ResultsTime-Lapse ImagingCarbocyaninesCY5.5 cyanine dyeErbB Receptors

Identifiers

PMID27874037
PMCPMC5118792
OpenAlexW2551998918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.