Evidence map›Paper›PMID 27874029›Full record

ArticleScientific reports2016

An anti-TNF-α antibody mimetic to treat ocular inflammation.

Hanieh Khalili, Richard W Lee, Peng T Khaw, Steve Brocchini, Andrew D Dick, David A Copland

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hanieh KhaliliUCL School of Pharmacy, London, UK.
Richard W LeeNational Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Peng T KhawNational Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Steve BrocchiniUCL School of Pharmacy, London, UK.
Andrew D DickNational Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
David A CoplandNational Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Moorfields Eye Hospital NHS Foundation Trust · GBNational Institute for Health Research · GBUniversity College London · GBUniversity of Bristol · GB

Funding

Medical Research Council
6 · The paper itself

Abstract

Infliximab is an antibody that neutralizes TNF-α and is used principally by systemic administration to treat many inflammatory disorders. We prepared the antibody mimetic Fab-PEG-Fab (FpF

Indexed as

AnimalsAntibodies, MonoclonalAntigen-Antibody ReactionsAutoimmune DiseasesDisease Models, AnimalEye DiseasesHumansImmunoglobulin Fab FragmentsInflammationInfliximabIntravitreal InjectionsLeukocyte Common AntigensMicePolyethylene GlycolsSurface Plasmon ResonanceTumor Necrosis Factor-alphaAntibodies, MonoclonalImmunoglobulin Fab FragmentsInfliximabLeukocyte Common AntigensPolyethylene GlycolsTumor Necrosis Factor-alpha

Identifiers

PMID27874029
PMCPMC5118814
OpenAlexW2555524718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.