ArticleeLife2016
Postprandial sleep mechanics in
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 111 citations in OpenAlex.
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Association of table salt use with sleep patterns and depressive symptoms: population-based analysis with external clinical replication.Frontiers in nutrition · 2026Article
- Energy Deficit Is a Key Driver of Sleep Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan.Nature metabolism · 2025Article
- Article
- A hormone-to-neuropeptide pathway inhibits sexual receptivity in immatureProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Siesta behavior and genetics interact to influence obesity risk.Obesity (Silver Spring, Md.) · 2025Article
- Postprandial Sleep in Short-Sleeping Mexican Cavefish.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- Mating reconciles fitness and fecundity by switching diet preference in flies.Nature communications · 2024Article
- Postprandial sleep in short-sleeping Mexican cavefish.bioRxiv : the preprint server for biology · 2024Article
- Effect of a Whole-Food Plant-Based Diet on Postprandial Sleepiness: A Pilot Study.American journal of lifestyle medicine · 2024Article
- The interplay between sleep and ecophysiology, behaviour and responses to environmental change in fish.The Journal of experimental biology · 2024Review
- Preference of position in the proximity of various sugars revealed by location analysis of Drosophila melanogaster.Scientific reports · 2024Article
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- Natural brain state change with E/I balance shifting toward inhibition is associated with vigilance impairment.iScience · 2023Article
- Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress.Current biology : CB · 2023Article
- Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Food consumption is thought to induce sleepiness. However, little is known about how postprandial sleep is regulated. Here, we simultaneously measured sleep and food intake of individual flies and found a transient rise in sleep following meals. Depending on the amount consumed, the effect ranged from slightly arousing to strongly sleep inducing. Postprandial sleep was positively correlated with ingested volume, protein, and salt-but not sucrose-revealing meal property-specific regulation. Silencing of leucokinin receptor (Lkr) neurons specifically reduced sleep induced by protein consumption. Thermogenetic stimulation of leucokinin (Lk) neurons decreased whereas Lk downregulation by RNAi increased postprandial sleep, suggestive of an inhibitory connection in the Lk-Lkr circuit. We further identified a subset of non-leucokininergic cells proximal to Lkr neurons that rhythmically increased postprandial sleep when silenced, suggesting that these cells are cyclically gated inhibitory inputs to Lkr neurons. Together, these findings reveal the dynamic nature of postprandial sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.