Evidence map›Paper›PMID 27873515›Full record

ArticleYonsei medical journal2017

Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats.

Zhi Wei Huang, Ning Liu, Dong Li, Hai Yan Zhang, Ying Wang, Yi Liu, Le Ling Zhang, Xiu Li Ju

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonsei medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  9. Soluble factors of mesenchimal stem cells (FS-MSC) as a potential tool to reduce inflammation in donor's lungs after hypovolemic shock.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhi Wei HuangDepartment of Hematology, The Qilu Childrens' Hospital, Shandong University, Jinan, Shandong Province, P.R. China.
Ning LiuDepartment of Hematology, The Qilu Childrens' Hospital, Shandong University, Jinan, Shandong Province, P.R. China.
Dong LiDepartment of Pediatrics, The Qilu Hospital of Shandong University, Jinan, Shandong Province, P.R. China.
Hai Yan ZhangDepartment of Hematology, The Qilu Childrens' Hospital, Shandong University, Jinan, Shandong Province, P.R. China.
Ying WangDepartment of Hematology, The Qilu Childrens' Hospital, Shandong University, Jinan, Shandong Province, P.R. China.
Yi LiuDepartment of Hematology, The Qilu Childrens' Hospital, Shandong University, Jinan, Shandong Province, P.R. China.
Le Ling ZhangDepartment of Hematology, The Qilu Childrens' Hospital, Shandong University, Jinan, Shandong Province, P.R. China. 2598260466@qq.com.
Xiu Li JuDepartment of Pediatrics, The Qilu Hospital of Shandong University, Jinan, Shandong Province, P.R. China. lyssyl88@sina.com.
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAngiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of endothelial permeability and leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord mesenchymal stem cells (UCMSCs) carrying the Ang1 gene (UCMSCs-Ang1) might be a potential approach for acute lung injury (ALI) induced by lipopolysaccharide (LPS). MATERIALS AND

methodsUCMSCs with or without transfection with the human Ang1 gene were delivered intravenously into rats one hour after intra-abdominal instillation of LPS to induce ALI. After the rats were sacrificed at 6 hours, 24 hours, 48 hours, 8 days, and 15 days post-injection of LPS, the serum, the lung tissues, and bronchoalveolar lavage fluid (BALF) were harvested for analysis, respectively.

resultsAdministration of fluorescence microscope confirmed the increased presence of UCMSCs in the injured lungs. The evaluation of UCMSCs and UCMSCs-Ang1 actions revealed that Ang1 overexpression further decreased the levels of the pro-inflammatory cytokines TNF-α, TGF-β₁, and IL-6 and increased the expression of the anti-inflammatory cytokine IL-10 in the injured lungs. This synergy caused a substantial decrease in lung airspace inflammation and vascular leakage, characterized by significant reductions in wet/dry ratio, differential neutrophil counts, myeloperoxidase activity, and BALF. The rats treated by UCMSCs-Ang1 showed improved survival and lower ALI scores.

conclusionUCMSCs-Ang1 could improve both systemic inflammation and alveolar permeability in ALI. UC-derived MSCs-based Ang1 gene therapy may be developed as a potential novel strategy for the treatment of ALI.

Indexed as

Mesenchymal Stem Cell TransplantationAcute Lung InjuryAngiopoietin-1AnimalsBronchoalveolar Lavage FluidCytokinesEndotoxinsGenetic TherapyInterleukin-10Interleukin-6Leukocyte CountLipopolysaccharidesLungMaleMesenchymal Stem CellsNeutrophilsAngiopoietin-1ANGPT1 protein, humanCytokinesEndotoxinsIL10 protein, humanInterleukin-10Interleukin-6LipopolysaccharidesTransforming Growth Factor beta1Tumor Necrosis Factor-alphaacute lung injuryAngiopoietin-1human umbilical cord mesenchymal stem cell

Identifiers

PMID27873515
PMCPMC5122639
OpenAlexW2554479467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.