Evidence map›Paper›PMID 27873510›Full record

SynthesisYonsei medical journal2017

Certain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis.

Shuai Zhang, Xue Bin Wang, Ya Di Han, Chen Wang, Ye Zhou, Fang Zheng

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Yonsei medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Article
  6. Review
  7. Review
  8. Offense and Defense in Granulomatous Inflammation Disease.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Disease markers · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shuai ZhangCenter for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Xue Bin WangCenter for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Ya Di HanCenter for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Chen WangCenter for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Ye ZhouCenter for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Fang ZhengCenter for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wuhan University · CNZhongnan Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNumerous studies have assessed the association of SP110 gene variants with tuberculosis (TB), but the results were inconsistent. Through a comprehensive review and meta-analysis, our study aimed to clarify the nature of genetic risks contributed by 11 polymorphisms for the development of TB. MATERIALS AND

methodsThrough searching PubMed, web of science, China National Knowledge Infrastructure (CNKI) databases, a total of 11 articles including 13 independent studies were selected. The pooled odd ratios (ORs) along with their corresponding 95% confidence interval (CI) were estimated for allelic comparisons, additive model (homozygote comparisons; heterozygote comparisons), dominant model and recessive model. We also assessed the heterogeneity across the studies and publication bias.

resultsThe results of combined analysis revealed a significantly increased risk of TB for single nucleotide polymorphism (SNP) rs9061 in all five comparisons (allelic comparisons: OR=1.28, 95% CI=1.14-1.44, p<0.0001; homozygote comparisons: OR=2.84, 95% CI=1.84-4.38, p<0.00001; heterozygote comparisons: OR=1.23, 95% CI=1.05-1.43, p=0.009; dominant model: OR=1.32, 95% CI=1.14-1.53, p=0.0003; recessive model: OR=2.26, 95% CI=1.18-4.34, p=0.01). In subgroup analysis, the risk of TB associated with SNP rs9061 appeared to be increased. Moreover, increased risk of TB was also found in Asian subgroup of SNP rs11556887, while decreased risk of TB appeared in large sample size subgroup of SNP rs1135791. No significant association was observed between other SNPs and the risk of TB.

conclusionOur meta-analysis suggested that the variant of SNP rs9061 might be a risk factor for TB.

Indexed as

Polymorphism, Single NucleotideAllelesAsian PeopleChinaConfidence IntervalsGenetic Predisposition to DiseaseHeterozygoteHomozygoteHumansMinor Histocompatibility AntigensNuclear ProteinsOdds RatioRisk FactorsTuberculosis, PulmonaryMinor Histocompatibility AntigensNuclear ProteinsSp110 protein, humanpolymorphismSpeckled 110 geneTuberculosis

Identifiers

PMID27873510
PMCPMC5122633
OpenAlexW2550322329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.