ArticleThe Laryngoscope2017
Dynamic nanomechanical analysis of the vocal fold structure in excised larynges.
Article in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Investigating the effects of vertical misalignment and stiffness asymmetry on phonation in a synthetic vocal fold model.The Journal of the Acoustical Society of America · 2026Article
- Drug delivery systems for wound healing treatment of upper airway injury.Expert opinion on drug delivery · 2024Review
- Changes in vocal fold gene expression and histology after injection augmentation in a recurrent laryngeal nerve injury model.The Journal of laryngology and otology · 2024Article
- Effect of Ligament Fibers on Dynamics of Synthetic, Self-Oscillating Vocal Folds in a Biomimetic Larynx Model.Bioengineering (Basel, Switzerland) · 2023Article
- Effect of continuous local dexamethasone on tissue biomechanics and histology after inhalational burn in a preclinical model.Laryngoscope investigative otolaryngology · 2023Article
- Effect of nodule size and stiffness on phonation threshold and collision pressures in a synthetic hemilaryngeal vocal fold model.The Journal of the Acoustical Society of America · 2023Article
- Collision Pressure and Dissipated Power Dose in a Self-Oscillating Silicone Vocal Fold Model With a Posterior Glottal Opening.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Augmentation and vocal fold biomechanics in a recurrent laryngeal nerve injury model.Laryngoscope investigative otolaryngology · 2022Article
- Vocal fold dynamics in a synthetic self-oscillating model: Intraglottal aerodynamic pressure and energy.The Journal of the Acoustical Society of America · 2021Article
- Vocal fold dynamics in a synthetic self-oscillating model: Contact pressure and dissipated-energy dose.The Journal of the Acoustical Society of America · 2021Article
- Investigating blunt force trauma to the larynx: The role of inferior-superior vocal fold displacement on phonation.Journal of biomechanics · 2021Article
- Quantifying vocal fold wound-healing biomechanical property changes.The Laryngoscope · 2020Article
- Development of Excised Larynx.Journal of voice : official journal of the Voice Foundation · 2020Review
- Toward Development of a Vocal Fold Contact Pressure Probe: Sensor Characterization and Validation Using Synthetic Vocal Fold Models.Applied sciences (Basel, Switzerland) · 2019Article
- Automated Indentation Mapping of Vocal Fold Structure and Cover Properties Across Species.The Laryngoscope · 2019Article
- Impact of medialization laryngoplasty on dynamic nanomechanical vocal fold structure properties.The Laryngoscope · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectives/hypothesisQuantification of clinical outcomes after vocal fold (VF) interventions is challenging with current technology. High-speed digital imaging and optical coherence tomography (OCT) of excised larynges assess intact laryngeal function, but do not provide critical biomechanical information. We developed a protocol to quantify tissue properties in intact, excised VFs using dynamic nanomechanical analysis (nano-DMA) to obtain precise biomechanical properties in the micrometer scale. STUDY
designExperimental animal study.
methodsThree pig larynges were bisected in the sagittal plane, maintaining an intact anterior commissure, and subjected to nano-DMA at nine locations with a 250-μm flat-tip punch and frequency sweep load profile (10-105 Hz, 1,000 μN peak force) across the free edge of the VF and inferiorly along the conus elasticus.
resultsStorage, loss, and complex moduli increased inferiorly from the free edge. Storage moduli increased from a mean of 32.3 kPa (range, 6.5-55.38 kPa) at the free edge to 46.3kPa (range, 7.4-71.6) 5 mm below the free edge, and 71.4 kPa (range, 33.7-112 kPa) 1 cm below the free edge. Comparable values were 11.6 kPa (range, 5.0-20.0 kPa), 16.7 kPa (range, 5.7-26.8 kPa), and 22.6 kPa (range, 9.7-38.0 kPa) for loss modulus, and 35.7 kPa (range, 14.4-56.4 kPa), 50.1 kPa (range, 18.7-72.8 kPa), and 75.4 kPa (range, 42.0-116.0 kPa) for complex modulus. Another larynx repeatedly frozen and thawed during technique development had similarly increased storage, loss, and complex modulus trends across locations.
conclusionsNano-DMA of the intact hemilarynx provides a platform for quantification of biomechanical responses to a myriad of therapeutic interventions to complement data from high-speed imaging and OCT. LEVEL OF EVIDENCE: NA Laryngoscope, 127:E225-E230, 2017.
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