ReviewInternational journal of bipolar disorders2016
Aims and structure of the German Research Consortium BipoLife for the study of bipolar disorder.
Review in International journal of bipolar disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Trajectories of affective disorders: neurobiological mechanisms during symptom change.Der Nervenarzt · 2026Review
- Creativity and transition to bipolar disorder: a prospective analysis from the early-bipolife study.International journal of bipolar disorders · 2025Article
- Advancing the prediction of factors associated with bipolar disorder risk: utilizing early recognition tools and polygenic risk scores.International journal of bipolar disorders · 2025Article
- Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.Biological psychiatry global open science · 2025Article
- Quality of life in persons at risk for bipolar disorder: a two year prospective-longitudinal observational cohort study (BipoLife).International journal of bipolar disorders · 2025Article
- Stressed! Grab a bite? Stress eating in adults with Attention-Deficit/Hyperactivity Disorder: An Ecological Momentary Assessment study.Neuroscience applied · 2025Article
- The German research consortium for the study of bipolar disorder (BipoLife): a quality assurance protocol for MR neuroimaging data.International journal of bipolar disorders · 2024Article
- Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.Molecular psychiatry · 2023Article
- Microtemporal Dynamics of Dietary Intake, Physical Activity, and Impulsivity in Adult Attention-Deficit/Hyperactivity Disorder: Ecological Momentary Assessment Study Within Nutritional Psychiatry.JMIR mental health · 2023Article
- Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes.Brain sciences · 2023Article
- Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.Research square · 2023Article
- The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol.International journal of bipolar disorders · 2021Article
- The growing field of digital psychiatry: current evidence and the future of apps, social media, chatbots, and virtual reality.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.Translational psychiatry · 2021Article
- Studying Microtemporal, Within-Person Processes of Diet, Physical Activity, and Related Factors Using the APPetite-Mobile-App: Feasibility, Usability, and Validation Study.Journal of medical Internet research · 2021Article
- Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife).International journal of bipolar disorders · 2020Article
- Risk Stratification for Bipolar Disorder Using Polygenic Risk Scores Among Young High-Risk Adults.Frontiers in psychiatry · 2020Article
- Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative.International journal of bipolar disorders · 2019Review
- Reporting guidelines on remotely collected electronic mood data in mood disorder (eMOOD)-recommendations.Translational psychiatry · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have so far not been unraveled. As a result, individual treatment decisions cannot be tailor-made and the uncertain prognosis is based on clinical characteristics alone. Although a subpopulation of patients have an excellent response to pharmacological monotherapy, other subpopulations have been less well served by the medical system and therefore require more focused attention. In particular individuals at high risk of bipolar disorder, young patients in the early stages of bipolar disorder, patients with an unstable highly relapsing course and patients with acute suicidal ideation have been identified as those in need. STRUCTURE: A research consortium of ten universities across Germany has therefore implemented a 4 year research agenda including three randomized controlled trials, one epidemiological trial and one cross-sectional trial to address these areas of unmet needs. The topics under investigation will be the improvement of early recognition, specific psychotherapy, and smartphones as an aid for early episode detection and biomarkers of lithium response. A subset of patients will be investigated utilizing neuroimaging (fMRI), neurophysiology (EEG), and biomaterials (genomics, transcriptomics).
conclusionsThis article aims to outline the rationale, design, and methods of these individual studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.