Evidence map›Paper›PMID 27873176›Full record

Trial reportInternational journal of hematology2017

Palonosetron, aprepitant, and dexamethasone for prevention of nausea and vomiting after high-dose melphalan in autologous transplantation for multiple myeloma: A phase II study.

Atsushi Isoda, Rie Saito, Fuminori Komatsu, Yuki Negishi, Noriyasu Oosawa, Tetsuya Ishikawa, Yuri Miyazawa, Morio Matsumoto, Morio Sawamura, Akihiro Manaka

Abstract readClinical Trial, Phase II
PubMed Publisher
In one paragraph

Trial report in International journal of hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Global inequitable distribution of seminal studies of chemotherapy-induced nausea and vomiting.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  3. Efficacy of intensive antiemetic therapy including olanzapine in multiple myeloma patients treated with high-dose melphalan with autologous stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Prevention of chemotherapy-induced nausea and vomiting after high-dose melphalan and stem cell transplantation: review of the evidence and suggestions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Atsushi IsodaDepartment of Hematology, National Hospital Organization Shibukawa Medical Center, 383 Shiroi, Shibukawa, Gunma, 377-0280, Japan. aisoda@sbmc.hosp.go.jp.
Rie SaitoDepartment of Pharmacy, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan.
Fuminori KomatsuDepartment of Pharmacy, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan.
Yuki NegishiDepartment of Pharmacy, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan.
Noriyasu OosawaDepartment of Pharmacy, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan.
Tetsuya IshikawaDepartment of Hematology, National Hospital Organization Shibukawa Medical Center, 383 Shiroi, Shibukawa, Gunma, 377-0280, Japan.
Yuri MiyazawaDepartment of Hematology, National Hospital Organization Shibukawa Medical Center, 383 Shiroi, Shibukawa, Gunma, 377-0280, Japan.
Morio MatsumotoDepartment of Hematology, National Hospital Organization Shibukawa Medical Center, 383 Shiroi, Shibukawa, Gunma, 377-0280, Japan.
Morio SawamuraDepartment of Clinical Research, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan.
Akihiro ManakaDepartment of Pharmacy, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan.
National Hospital Organization · JPGunma University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy-induced nausea and vomiting (CINV) is a significant side effect in multiple myeloma (MM) patients receiving high-dose melphalan treatment followed by autologous stem cell transplantation (ASCT). We evaluated the efficacy and safety of a triple antiemetic combination of palonosetron, aprepitant, and low-dose dexamethasone in 24 MM patients who received melphalan conditioning (100 mg/m

Indexed as

AdultAgedAntiemeticsAprepitantDexamethasoneDrug Therapy, CombinationHumansIsoquinolinesMelphalanMiddle AgedMorpholinesMultiple MyelomaMyeloablative AgonistsPalonosetronPostoperative Nausea and VomitingQuinuclidinesAntiemeticsAprepitantDexamethasoneIsoquinolinesMelphalanMorpholinesMyeloablative AgonistsPalonosetronQuinuclidinesAprepitantHigh-dose melphalanMultiple myelomaNauseaPalonosetron

Identifiers

PMID27873176
OpenAlexW2555285636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.