Evidence map›Paper›PMID 27873143›Full record

ArticleMolecular and cellular biochemistry2017

Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4.

Crystal Sidhu, Appalaraju Jaggupilli, Prashen Chelikani, Rajinder P Bhullar

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Crystal SidhuDepartment of Oral Biology, University of Manitoba, Rm. D328, Winnipeg, MB, R3E 0W2, Canada.
Appalaraju JaggupilliDepartment of Oral Biology, University of Manitoba, Rm. D328, Winnipeg, MB, R3E 0W2, Canada.
Prashen ChelikaniDepartment of Oral Biology, University of Manitoba, Rm. D328, Winnipeg, MB, R3E 0W2, Canada.
Rajinder P BhullarDepartment of Oral Biology, University of Manitoba, Rm. D328, Winnipeg, MB, R3E 0W2, Canada. Rajinder.Bhullar@umanitoba.ca.
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rac1 belongs to the Rho family of small GTPases and regulates actin cytoskeleton reorganization. T2R4 is a bitter taste receptor belonging to the G protein-coupled receptor family of proteins. In addition to mediating bitter taste perception from the tongue, T2R4s are found in extra-oral tissues, e.g., nasal epithelium, airways, brain, testis suggesting a much broader physiological function for these receptors. Anti-malarial drug and a bitter tasting compound, quinine, is a known agonist for T2R4, whereas BCML (Nα,Nα-Bis(carboxymethyl)-L-lysine) acts as an inverse agonist. Using western blot and Ca

Indexed as

GTP-Binding Protein alpha Subunits, Gq-G11HEK293 CellsHumansQuininerac1 GTP-Binding ProteinReceptors, G-Protein-CoupledSignal TransductionTaste Receptors, Type 2G protein alpha 16GTP-Binding Protein alpha Subunits, Gq-G11Quininerac1 GTP-Binding ProteinRAC1 protein, humanReceptors, G-Protein-CoupledTaste Receptors, Type 2Bitter taste receptorG-alpha proteinG protein-coupled receptorQuinineRac1 inactivation

Identifiers

PMID27873143
OpenAlexW2552660438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.