Evidence map›Paper›PMID 27872984›Full record

ArticleCardiovascular and interventional radiology2017

Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma.

Luke R Wilkins, David L Brautigan, Hanping Wu, Hooman Yarmohammadi, Ewa Kubicka, Vlad Serbulea, Norbert Leitinger, Wendy Liu, John R Haaga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular and interventional radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  4. Caffeic Acid and Diseases-Mechanisms of Action.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Luke R WilkinsDepartment of Radiology and Medical Imaging, University of Virginia Health Systems, 1215 Lee Street, Box 800170, Charlottesville, VA, 22908, USA. lrw6n@virginia.edu.
David L BrautiganDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, 22908, USA.
Hanping WuDepartment of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, 44106, USA.
Hooman YarmohammadiDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
Ewa KubickaDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, 22908, USA.
Vlad SerbuleaDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22908, USA.
Norbert LeitingerDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22908, USA.
Wendy LiuDepartment of Pathology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, 44106, USA.
John R HaagaDepartment of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, 44106, USA.
University of Virginia · USUniversity Hospitals of Cleveland · USCase Western Reserve University · USMemorial Sloan Kettering Cancer Center · USUniversity of Virginia Health System · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

introductionWe hypothesize that the combination of transarterial embolization (TAE) plus inhibition of lactate export will limit anaerobic metabolism and reduce tumor survival compared to TAE alone. The purpose of this study was to test this hypothesis in a rat model of hepatocellular carcinoma (HCC).

methodsRat N1-S1 hepatoma cells were assayed in vitro using the Seahorse XF analyzer to measure extracellular acidification (lactate excretion) comparing effects of the addition of caffeic acid (CA) or ferulic acid (FA) or UK-5099 with control. Monocarboxylate transporter Slc16a3 was knocked down by RNAi. N1S1 tumors were orthotopically implanted in rats and 4 groups evaluated: (1) Control, (2) TAE-only, (3) TAE plus CA, and (4) TAE plus FA. Tumor size was determined by ultrasound and analyzed by repeated measures statistics. Tumors harvested at 4 weeks were examined by microscopy.

resultsSeahorse assays showed that CA and FA caused a significant reduction by >90% in lactate efflux by N1S1 tumor cells (p < 0.01). Knockdown of Slc16a3 prevented inhibition by CA. In vivo tumors grew 30-fold in volume over 4 weeks in untreated controls. By comparison, TAE resulted in near cessation of growth (10% in 4-week time period). However, both TAE + CA and TAE + FA caused a significant reduction of tumor volumes (87 and 72%, respectively) compared to control and TAE (p < 0.05). Pathologic evaluation revealed residual tumor in the TAE group but no residual viable tumor cells in the TAE + CA and TAE + FA groups.

conclusionAddition of CA or FA enhances the effectiveness of TAE therapy for HCC in part by blocking lactate efflux.

Indexed as

Disease Models, AnimalAcrylatesAnimalsCaffeic AcidsCell Line, TumorCoumaric AcidsEmbolization, TherapeuticFemaleLactic AcidLiver NeoplasmsLiver Neoplasms, ExperimentalMaleNeoplasm TransplantationRatsTreatment OutcomeTumor Burden2-cyano-3-(1-phenylindol-3-yl)acrylateAcrylatescaffeic acidCaffeic AcidsCoumaric Acidsferulic acidLactic AcidEmbolizationInterventional oncologyLactateTranslationalTumor metabolism

Identifiers

PMID27872984
PMCPMC5520990
OpenAlexW2556147027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.