ArticleWorld journal of surgery2017
Identification of Recurrence-Predictive Indicators in Stage I Colorectal Cancer.
Article in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Is tumour location a dominant risk factor of recurrence in early rectal cancer?Surgical endoscopy · 2025Article
- Risk factors for recurrence in stage I colorectal cancer after curative resection: a systematic review and meta-analysis.Annals of surgical treatment and research · 2025Article
- Vertical margin distance in T1 colorectal carcinoma resected by endoscopic submucosal dissection affects prognosis after additional surgery.International journal of colorectal disease · 2024Article
- Determinants of survival and recurrence in patients with stage I colorectal cancer.Frontiers in surgery · 2024Article
- Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts.BMC medicine · 2023Article
- Preoperative prediction of lymphovascular invasion of colorectal cancer by radiomics based on 18F-FDG PET-CT and clinical factors.Frontiers in radiology · 2023Article
- Clinical study on risk factors related to postoperative recurrence or metastasis of rectal cancer: a retrospective cohort study.Journal of gastrointestinal oncology · 2022Article
- Letter to the Editor regarding the identification of high‑risk stage I colon and rectal cancer patients: a retrospective analysis of a large Japanese cohort.International journal of colorectal disease · 2022Article
- Identification of high-risk stage I colon and rectal cancer patients: a retrospective analysis of a large Japanese cohort.International journal of colorectal disease · 2022Article
- Perineural invasion and number of retrieved lymph nodes are prognostic factors for T2N0 colon cancer.Langenbeck's archives of surgery · 2021Article
- Optimal cutoff value of preoperative CEA and CA19-9 for prognostic significance in patients with stage II/III colon cancer.Langenbeck's archives of surgery · 2021Article
- The risk factors of local recurrence and distant metastasis on pT1/T2N0 mid-low rectal cancer after total mesorectal excision.World journal of surgical oncology · 2021Article
- Recurrence, death risk, and related factors in patients with stage 0 colorectal cancer: A nationwide population-based study.Medicine · 2020Article
- The clinical influence of the preoperative lymphocyte-to-monocyte ratio on the postoperative outcome of patients with early-stage gastrointestinal cancer.Annals of gastroenterological surgery · 2020Article
- Long-term Transanal Excision Outcomes in Patients With T1 Rectal Cancer: Comparative Analysis of Radical Resection.Annals of coloproctology · 2019Article
- The Value of the C-Reactive Protein-to-Albumin Ratio is Useful for Predicting Survival of Patients with Child-Pugh Class A Undergoing Liver Resection for Hepatocellular Carcinoma.World journal of surgery · 2018Article
- Article
- Identification of Recurrence: Predictive Indicators in Stage I Colorectal Cancer.World journal of surgery · 2017Article
- Identification of Recurrence-Predictive Indicators in Stage I Colorectal Cancer: Reply.World journal of surgery · 2017Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with stage I colorectal cancer (CRC) rarely experience recurrences; therefore, few risk factors for recurrence are known. This study was designed to evaluate oncologic outcomes of patients with stage I CRC and to identify risk factors for recurrence after curative surgery.
methodsA retrospective cohort of 860 patients from a single institution who underwent curative surgery for stage I CRC between July 1995 and June 2010 was enrolled. Patients who were diagnosed with hereditary, synchronous, or metachronous cancer and those who received preoperative chemoradiotherapy were excluded. Patients from whom fewer than 12 lymph nodes were retrieved were also excluded.
resultsThe 860 patients included 402 (46.7%) with colon tumors and 458 (53.3%) with rectal tumors. Thirty-five patients (4.1%) experienced recurrences; local and systemic recurrence rates were 1.1 and 3.0%, respectively. The 5-year overall survival and recurrence-free survival (RFS) rates were 93.5 ± 0.8% and 95.7 ± 0.8%, respectively. Multivariate analysis showed that preoperative serum carcinoembryonic antigen (CEA) concentration ≥6 ng/mL (hazard ratio [HR] 3.354, 95% confidence interval [CI] 1.373-8.195, p = 0.008) and lymphovascular invasion (LVI) (HR 2.676, 95% CI 1.097-6.531, p = 0.031) were independent risk factors for RFS.
conclusionsThe overall recurrence rate among patients with stage I CRC after curative surgery was 4.1%. Elevated serum CEA and LVI were significantly associated with recurrence. Large-scale, multicenter studies are needed to confirm the prognostic value of these risk factors.
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