ReviewFrontiers in immunology2016
Stress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and Maintenance.
Review in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging.Immunity · 2026Article
- Hematological consequences of environmental change during dewilding of rhesus macaques.Nature communications · 2026Article
- Mitochondrial transfer in the HSC-HCC-macrophage network shapes hepatocellular carcinoma progression.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Insights in bone marrow failure syndromes: take home messages from the 3rd ESH-EBMT-EHA-IPIG translational research conference.Bone marrow transplantation · 2025Article
- Hematological Consequences of Environmental Change During Dewilding of Rhesus Macaques.Research square · 2025Article
- Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation.Science China. Life sciences · 2025Article
- Cellular stress and epigenetic regulation in adult stem cells.Life science alliance · 2024Review
- Molecular mechanisms promoting long-term cytopenia after BCMA CAR-T therapy in multiple myeloma.Blood advances · 2024Article
- Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis.Science (New York, N.Y.) · 2024Article
- Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus.Biology of sex differences · 2024Article
- Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor.Brain, behavior, and immunity · 2024Article
- Systematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition.BMC biology · 2024Article
- Nucleic acid-induced inflammation on hematopoietic stem cells.Experimental hematology · 2024Article
- Sexually dimorphic role of diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus.bioRxiv : the preprint server for biology · 2023Article
- Article
- Rapid activation of hematopoietic stem cells.Stem cell research & therapy · 2023Article
- Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases?Frontiers in immunology · 2023Review
- Repeat Element Activation-Driven Inflammation: Role of NFκB and Implications in Normal Development and Cancer?Biomedicines · 2022Review
- Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis.Journal of leukocyte biology · 2022Review
- Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development.Cell death and differentiation · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoietic stem cells (HSCs) are a rare population that gives rise to almost all cells of the hematopoietic system, including immune cells. Until recently, it was thought that immune cells sense inflammatory signaling and HSCs respond only secondarily to these signals. However, it was later shown that adult HSCs could directly sense and respond to inflammatory signals, resulting in a higher output of immune cells. Recent studies demonstrated that inflammatory signaling is also vital for HSC ontogeny. These signals are thought to arise in the absence of pathogens, are active during development, and indispensable for HSC formation. In contrast, during times of stress and disease, inflammatory responses can be activated and can have devastating effects on HSCs. In this review, we summarize the current knowledge about inflammatory signaling in HSC development and maintenance, as well as the endogenous molecular cues that can trigger inflammatory pathway activation. Finally, we comment of the role of inflammatory signaling in hematopoietic diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.