Evidence map›Paper›PMID 27872619›Full record

ArticleFrontiers in microbiology2016

Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.

Michelle L Pleet, Allison Mathiesen, Catherine DeMarino, Yao A Akpamagbo, Robert A Barclay, Angela Schwab, Sergey Iordanskiy, Gavin C Sampey, Benjamin Lepene, Sergei Nekhai and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
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  10. Article
  11. Extracellular Vesicles and Viruses: Two Intertwined Entities.International journal of molecular sciences · 2023
    Review
  12. Extracellular vesicle storm during the course of Ebola virus infection in primates.Frontiers in cellular and infection microbiology · 2023
    Article
  13. Article
  14. Article
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  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Michelle L PleetLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas VA, USA.
Allison MathiesenDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk VA, USA.
Catherine DeMarinoLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas VA, USA.
Yao A AkpamagboLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas VA, USA.
Robert A BarclayLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas VA, USA.
Angela SchwabLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas VA, USA.
Sergey IordanskiyResearch Center for Neglected Diseases of Poverty, Department of Microbiology, Immunology and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington DC, USA.
Gavin C SampeyLaboratory of Molecular Virology, School of Systems Biology, George Mason University, ManassasVA, USA; University of North Carolina HIV Cure Center, Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel HillNC, USA.
Benjamin LepeneCeres Nanosciences Inc., Manassas VA, USA.
Sergei NekhaiCenter for Sickle Cell Disease, Department of Medicine, Howard University, Washington DC, USA.
M J AmanIntegrated BioTherapeutics, Inc., Gaithersburg MD, USA.
Fatah KashanchiLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas VA, USA.
George Mason University · USThe University of Texas Medical Branch at Galveston · USCeres Nanosciences · USEastern Virginia Medical School · USGeorge Washington University · USHoward University · USIntegrated BioTherapeutics (United States) · US

Funding

Therapeutics Targeting Filoviral interferon-antagonist and replication functionsU19AI109664 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASLER, CHRISTOPHER F · 2014 to 2018
$15.8M
Center for Hemoglobin Research in Minorities (CHaRM)P50HL118006 · NHLBI · HOWARD UNIVERSITY · PI NEKHAI, SERGEI · 2013 to 2017
$7.0M
HIV1 INHIBITION USING TAT PEPTIDE DERIVATIVESR01AI043894 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KASHANCHI, FATAH · 1999 to 2015
$4.4M
HIV neuropathogenesis related to exosomes containing HIV non-coding RNAsR01NS099029 · NINDS · GEORGE MASON UNIVERSITY · PI KASHANCHI, FATAH · 2016 to 2020
$1.9M
Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcriptionR21AI074410 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI KASHANCHI, FATAH · 2009 to 2010
$432k
Nanotrap particle-based assay to quantify HIV-1 in latently-infected T cellsR21AI113140 · NIAID · GEORGE MASON UNIVERSITY · PI KASHANCHI, FATAH · 2014 to 2015
$409k
HIV-1 TAR derived miRNA: Implications for Latency and PathogenesisR21AI078859 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI KASHANCHI, FATAH · 2009 to 2010
$400k
NHLBI NIH HHS P50 HL118006NIAID NIH HHS R01 AI043894NIAID NIH HHS R21 AI074410NIAID NIH HHS R21 AI078859NIAID NIH HHS R21 AI113140NIAID NIH HHS U19 AI109664NINDS NIH HHS R01 NS099029
6 · The paper itself

Abstract

Ebola virus (EBOV) is an enveloped, ssRNA virus from the family

Indexed as

apoptosisEbola virusEBOVESCRTexosomesmicroRNAVLPVP40

Identifiers

PMID27872619
PMCPMC5098130
OpenAlexW2549557444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.