Evidence map›Paper›PMID 27872611›Full record

ArticleFrontiers in microbiology2016

Hypocholesterolemic and Prebiotic Effects of a Whole-Grain Oat-Based Granola Breakfast Cereal in a Cardio-Metabolic "At Risk" Population.

Michael L Connolly, Xenofon Tzounis, Kieran M Tuohy, Julie A Lovegrove

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01925365 (Hypocholesterolaemic and Prebiotic Effects of a Whole-grain Oat-based Breakfast Cereal in a Cardio-metabolic 'at Risk' Population), which is not on this map. Cited by 38 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 9 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01925365 nacompletednot on this map

Hypocholesterolaemic and Prebiotic Effects of a Whole-grain Oat-based Breakfast Cereal in a Cardio-metabolic 'at Risk' Population

TypeinterventionalSponsorUniversity of ReadingRan2009 to 2010Enrolled30ConditionsCardiovascular Disease, HypercholesterolemiaArmswholegrain cereals oats (WGO), Non wholegrain cereals
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 9 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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  6. Effects of Oats (Frontiers in nutrition · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Michael L ConnollyHugh Sinclair Unit of Human Nutrition, University of ReadingReading, UK; Institute for Cardiovascular and Metabolic Research, University of ReadingReading, UK.
Xenofon TzounisHugh Sinclair Unit of Human Nutrition, University of ReadingReading, UK; Institute for Cardiovascular and Metabolic Research, University of ReadingReading, UK.
Kieran M TuohyHugh Sinclair Unit of Human Nutrition, University of ReadingReading, UK; Department of Food Quality and Nutrition, Research and Innovation Centre - Fondazione Edmund MachTrento, Italy.
Julie A LovegroveHugh Sinclair Unit of Human Nutrition, University of ReadingReading, UK; Institute for Cardiovascular and Metabolic Research, University of ReadingReading, UK.
University of Reading · GBFondazione Edmund Mach · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meta-analyses of randomized controlled trials (RTC) have confirmed the hypocholesterolaemic effect of oats and oat based fibers. However, the mechanisms by which oats or oat fractions lower cholesterol is not totally clear. Recognizing the important role of the gut microbiome in metabolism and metabolic disease risk, we examined the impact of whole grain oat Granola (WGO) on the human gut microbiota and cardio-metabolic risk factors using a randomized crossover dietary intervention in at risk individuals (ClinicalTrials.gov Identifier: NCT01925365). We randomized 32 individuals at risk of developing cardio-metabolic disease by virtue of mild hypercholesterolaemia or glucose intolerance, into two groups consuming either 45 g of WGO or non-whole grain (NWG) breakfast cereals daily for two 6-week intervention periods separated by a 4-week wash out period in a randomized, controlled, crossover, double-blinded design. Confirming the cholesterol lowering effect of WGO, we observed a significant time by treatment interaction, for total cholesterol (TC) (

Indexed as

Bifidobacteriumcardiovascular riskcholesterolprebioticwhole-grain oat granola

Identifiers

PMID27872611
PMCPMC5098205
OpenAlexW2549215583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.