Evidence map›Paper›PMID 27872595›Full record

ReviewFrontiers in physiology2016

Redox Mechanism of Reactive Oxygen Species in Exercise.

Feng He, Juan Li, Zewen Liu, Chia-Chen Chuang, Wenge Yang, Li Zuo

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 207 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 6 pooled it
32.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06511960 nacompletednot on this mapstarted 2023, after this paper: background citation

Impact of Four Weeks of Astaxanthin Supplementation at Varied Doses on Muscle Pain, Muscle Damage Markers, and Total Antioxidant Status in Exercising Males: A Randomized Controlled Trial

TypeinterventionalSponsorHacettepe UniversityRan2023 to 2024Enrolled24ConditionsDietary SupplementsArmsAstaxanthin (12 mg/day) intervention, 36 mg/day astaxanthin intervention, Placebo
NCT07114341 nacompletednot on this mapstarted 2025, after this paper: background citation

Effect of Lyophilized Cornelian Cherry on Anaerobic Performance in Young Football Players

TypeinterventionalSponsorIstanbul Bilgi UniversityRan2025 to 2025Enrolled50ConditionsSport Nutrition, Sports Performance in Children, Ergogenic Athletic Performance, Ergogenic SupportArmsCranberry Intervention
3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 6 syntheses or guidelines pooled it, 362 citations in OpenAlex.

  1. Effects ofNutrients · 2026
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  9. 6-Week Supplementation withInternational journal of environmental research and public health · 2022
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147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Feng HeDepartment of Kinesiology, California State University-Chico Chico, CA, USA.
Juan LiDepartment of Physical Education, Anhui University Anhui, China.
Zewen LiuAffiliated Ezhou Central Hospital at Medical School of Wuhan UniversityHubei, China; Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of MedicineColumbus, OH, USA.
Chia-Chen ChuangRadiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of MedicineColumbus, OH, USA; Interdisciplinary Biophysics Graduate Program, The Ohio State UniversityColumbus, OH, USA.
Wenge YangDepartment of Physical Education, China University of Geosciences Beijing, China.
Li ZuoRadiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of MedicineColumbus, OH, USA; Interdisciplinary Biophysics Graduate Program, The Ohio State UniversityColumbus, OH, USA.
The Ohio State University · USAnhui University · CNCalifornia State University, Chico · USChina University of Geosciences (Beijing) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well known that regular exercise can benefit health by enhancing antioxidant defenses in the body. However, unaccustomed and/or exhaustive exercise can generate excessive reactive oxygen species (ROS), leading to oxidative stress-related tissue damages and impaired muscle contractility. ROS are produced in both aerobic and anaerobic exercise. Mitochondria, NADPH oxidases and xanthine oxidases have all been identified as potential contributors to ROS production, yet the exact redox mechanisms underlying exercise-induced oxidative stress remain elusive. Interestingly, moderate exposure to ROS is necessary to induce body's adaptive responses such as the activation of antioxidant defense mechanisms. Dietary antioxidant manipulation can also reduce ROS levels and muscle fatigue, as well as enhance exercise recovery. To elucidate the complex role of ROS in exercise, this review updates on new findings of ROS origins within skeletal muscles associated with various types of exercises such as endurance, sprint and mountain climbing. In addition, we will examine the corresponding antioxidant defense systems as well as dietary manipulation against damages caused by ROS.

Indexed as

dietary antioxidantexerciseexercise-induced adaptationROSskeletal muscle

Identifiers

PMID27872595
PMCPMC5097959
OpenAlexW2548757381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.