Evidence map›Paper›PMID 27872583›Full record

ArticleFrontiers in cellular neuroscience2016

Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability

Daniela Weth-Malsch, Michiel Langeslag, Dimitra Beroukas, Luca Zangrandi, Iris Kastenberger, Serena Quarta, Philipp Malsch, Theodora Kalpachidou, Christoph Schwarzer, Richard L Proia and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Dysregulation of sphingolipid metabolism in pain.Frontiers in pharmacology · 2024
    Review
  4. Article
  5. Article
  6. The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Daniela Weth-MalschDivision of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck Innsbruck, Austria.
Michiel LangeslagDivision of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck Innsbruck, Austria.
Dimitra BeroukasAnatomy and Histology and Centre for Neuroscience, Flinders University Adelaide, SA, Australia.
Luca ZangrandiDepartment of Pharmacology, Medical University of Innsbruck Innsbruck, Austria.
Iris KastenbergerDepartment of Pharmacology, Medical University of Innsbruck Innsbruck, Austria.
Serena QuartaDivision of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck Innsbruck, Austria.
Philipp MalschDivision of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck Innsbruck, Austria.
Theodora KalpachidouDivision of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck Innsbruck, Austria.
Christoph SchwarzerDepartment of Pharmacology, Medical University of Innsbruck Innsbruck, Austria.
Richard L ProiaGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, MD, USA.
Rainer V HaberbergerAnatomy and Histology and Centre for Neuroscience, Flinders University Adelaide, SA, Australia.
Michaela KressDivision of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck Innsbruck, Austria.
Universität Innsbruck · ATFlinders University · AUInnsbruck Medical University · ATNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Sphingolipid Biology of NeurodegenerationZIADK056016 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2025
$21.3M
Mouse Models of Novel Sphingolipid Biology and Disease MechanismsZIADK056014 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2025
$10.6M
6 · The paper itself

Abstract

Understanding the role of the bioactive lipid mediator sphingosine 1-phosphate (S1P) within the central nervous system has recently gained more and more attention, as it has been connected to major diseases such as multiple sclerosis and Alzheimer's disease. Even though much data about the functions of the five S1P receptors has been collected for other organ systems, we still lack a complete understanding for their specific roles, in particular within the brain. Therefore, it was the aim of this study to further elucidate the role of S1P receptor subtype 3 (S1P

Indexed as

hippocampusneuron excitabilityS1P receptor 3sphingosine 1-phosphateworking memory

Identifiers

PMID27872583
PMCPMC5097928
OpenAlexW2548026357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.