ArticleProceedings of the National Academy of Sciences of the United States of America2016
The earliest maize from San Marcos Tehuacán is a partial domesticate with genomic evidence of inbreeding.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
- Multi-isotope analysis of mammal bones provides environmental context for the adoption of agriculture in the Tehuacan Valley of Mexico.Science advances · 2026Article
- The Evolutionary Dynamics of Genetic Mutational Load Throughout Tomato Domestication History.Molecular ecology · 2025Article
- Fifteenth century CE Bolivian maize reveals genetic affinities with ancient Peruvian maize.eLife · 2025Article
- In silico analysis of the evolution of root phenotypes during maize domestication in Neolithic soils of Tehuacán.The New phytologist · 2025Article
- An ancient origin of the naked grains of maize.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Archaeological findings show the extent of primitive characteristics of maize in South America.Science advances · 2024Article
- Domestication and the evolution of crops: variable syndromes, complex genetic architectures, and ecological entanglements.The Plant cell · 2024Review
- Unraveling the diversity and cultural heritage of fruit crops through paleogenomics.Trends in genetics : TIG · 2024Review
- Tracking population structure and phenology through time using ancient genomes from waterlogged white oak wood.Molecular ecology · 2024Article
- Article
- Conservation and diversity of the pollen microbiome of Pan-American maize using PacBio and MiSeq.Frontiers in microbiology · 2023Article
- Trans-Holocene Bayesian chronology for tree and field crop use from El Gigante rockshelter, Honduras.PloS one · 2023Article
- Genome Sequencing of up to 6,000-Year-Old Citrullus Seeds Reveals Use of a Bitter-Fleshed Species Prior to Watermelon Domestication.Molecular biology and evolution · 2022Article
- Maize dispersal patterns associated with different types of endosperm and migration of indigenous groups in lowland South America.Annals of botany · 2022Article
- Gradual domestication of root traits in the earliest maize from Tehuacán.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- South-to-north migration preceded the advent of intensive farming in the Maya region.Nature communications · 2022Article
- Plastome genomics in South American maize landraces: chloroplast lineages parallel the geographical structuring of nuclear gene pools.Annals of botany · 2021Article
- High-Throughput Genotyping Technologies in Plant Taxonomy.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Archaeological Central American maize genomes suggest ancient gene flow from South America.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Early isotopic evidence for maize as a staple grain in the Americas.Science advances · 2020Article
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7 authors.
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Abstract
Pioneering archaeological expeditions lead by Richard MacNeish in the 1960s identified the valley of Tehuacán as an important center of early Mesoamerican agriculture, providing by far the widest collection of ancient crop remains, including maize. In 2012, a new exploration of San Marcos cave (Tehuacán, Mexico) yielded nonmanipulated maize specimens dating at a similar age of 5,300-4,970 calibrated y B.P. On the basis of shotgun sequencing and genomic comparisons to Balsas teosinte and modern maize, we show herein that the earliest maize from San Marcos cave was a partial domesticate diverging from the landraces and containing ancestral allelic variants that are absent from extant maize populations. Whereas some domestication loci, such as teosinte branched1 (tb1) and brittle endosperm2 (bt2), had already lost most of the nucleotide variability present in Balsas teosinte, others, such as teosinte glume architecture1 (tga1) and sugary1 (su1), conserved partial levels of nucleotide variability that are absent from extant maize. Genetic comparisons among three temporally convergent samples revealed that they were homozygous and identical by descent across their genome. Our results indicate that the earliest maize from San Marcos was already inbred, opening the possibility for Tehuacán maize cultivation evolving from reduced founder populations of isolated and perhaps self-pollinated individuals.
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