Evidence map›Paper›PMID 27872304›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Evidence of isotopic fractionation of natural uranium in cultured human cells.

Eduardo Paredes, Emilie Avazeri, Véronique Malard, Claude Vidaud, Pascal E Reiller, Richard Ortega, Anthony Nonell, Hélène Isnard, Frédéric Chartier, Carole Bresson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Uranium Isotopes: From Geosciences to Biomedical Sciences.Current environmental health reports · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Radiation-related health hazards to uranium miners.Environmental science and pollution research international · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Eduardo ParedesDen-Service d'Etudes Analytiques et de Réactivité des Surfaces (SEARS), Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA), Université Paris-Saclay, F-91191 Gif sur Yvette, France; edes.PAREDES-PAREDES@cea.fr carole.bresson@cea.fr.
Emilie AvazeriCEA, Direction de la Recherche Fondamentale (DRF), Biosciences and Biotechnologies Institute (BIAM), F-30207 Bagnols-sur-Cèze, France.
Véronique MalardCEA, Direction de la Recherche Fondamentale (DRF), Biosciences and Biotechnologies Institute (BIAM), F-30207 Bagnols-sur-Cèze, France.
Claude VidaudCEA, Direction de la Recherche Fondamentale (DRF), Biosciences and Biotechnologies Institute (BIAM), F-30207 Bagnols-sur-Cèze, France.
Pascal E ReillerDen-Service d'Etudes Analytiques et de Réactivité des Surfaces (SEARS), Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA), Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Richard OrtegaUniversité de Bordeaux, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), UMR 5797, F-33170 Gradignan, France.
Anthony NonellDen-Service d'Etudes Analytiques et de Réactivité des Surfaces (SEARS), Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA), Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Hélène IsnardDen-Service d'Etudes Analytiques et de Réactivité des Surfaces (SEARS), Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA), Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Frédéric ChartierDen-Département de Physico-Chimie (DPC), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Carole BressonDen-Service d'Etudes Analytiques et de Réactivité des Surfaces (SEARS), Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA), Université Paris-Saclay, F-91191 Gif sur Yvette, France; edes.PAREDES-PAREDES@cea.fr carole.bresson@cea.fr.
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRUniversité Paris-Saclay · FRCEA Cadarache · FRCEA Paris-Saclay · FRInstitut de Biosciences et Biotechnologies · FRUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of the isotopic fractionation of endogen elements and toxic heavy metals in living organisms for biomedical applications, and for metabolic and toxicological studies, is a cutting-edge research topic. This paper shows that human neuroblastoma cells incorporated small amounts of uranium (U) after exposure to 10 µM natural U, with preferential uptake of the

Indexed as

Cell Culture TechniquesCell LineChemical FractionationHumansIsotopesNeuronsUraniumIsotopesUraniumanalytical procedure developmentisotopic fractionationmicrosamplesneuronal cellsuranium

Identifiers

PMID27872304
PMCPMC5150385
OpenAlexW2554916270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.