ArticleProceedings of the National Academy of Sciences of the United States of America2016
Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
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- Genetic Characterization and Population Structure of Drug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- The impact of conflict on infectious disease: a systematic literature review.Conflict and health · 2024Review
- The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions.The Journal of clinical investigation · 2023Review
- The Global Success of Mycobacterium tuberculosis Modern Beijing Family Is Driven by a Few Recently Emerged Strains.Microbiology spectrum · 2023Article
- Impact of wars and natural disasters on emerging and re-emerging infectious diseases.Frontiers in public health · 2023Review
- Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis.Nature communications · 2022Article
- Understanding drivers of phylogenetic clustering and terminal branch lengths distribution in epidemics ofeLife · 2022Article
- Reasons for Knocking at an Empty House: Visualisation, Representation and Dissemination of Health-Related Public Engagement Media.Advances in experimental medicine and biology · 2022Article
- Evolution ofFrontiers in cellular and infection microbiology · 2022Review
- Revised nomenclature and SNP barcode forMicrobial genomics · 2021Article
- The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis.FEMS microbiology reviews · 2021Review
- Accounting for the Biological Complexity of Pathogenic Fungi in Phylogenetic Dating.Journal of fungi (Basel, Switzerland) · 2021Review
- Evolutionary Genetics ofMicroorganisms · 2021Review
- Multiple Merger Genealogies in Outbreaks of Mycobacterium tuberculosis.Molecular biology and evolution · 2021Article
- Review
- Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak.PLoS pathogens · 2020Article
- Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV.International journal of environmental research and public health · 2020Article
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Authors and funding
14 authors at 5 institutions in 4 countries.
Funding
Abstract
The "Beijing" Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has been associated with accelerated disease progression and increased antibiotic resistance. Here we performed a phylodynamic reconstruction of one of the L2 sublineages, the central Asian clade (CAC), which has recently spread to western Europe. We find that recent historical events have contributed to the evolution and dispersal of the CAC. Our timing estimates indicate that the clade was likely introduced to Afghanistan during the 1979-1989 Soviet-Afghan war and spread further after population displacement in the wake of the American invasion in 2001. We also find that drug resistance mutations accumulated on a massive scale in Mtb isolates from former Soviet republics after the fall of the Soviet Union, a pattern that was not observed in CAC isolates from Afghanistan. Our results underscore the detrimental effects of political instability and population displacement on tuberculosis control and demonstrate the power of phylodynamic methods in exploring bacterial evolution in space and time.
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