Evidence map›Paper›PMID 27872281›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring.

Pablo Miranda, Teresa Giraldez, Miguel Holmgren

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Potential therapeutic targeting of BKMolecular oncology · 2026
    Review
  3. Article
  4. Mitochondrial potassium channels: A novel calcitriol target.Cellular & molecular biology letters · 2022
    Article
  5. Regulatory mechanisms of mitochondrial BKChannels (Austin, Tex.) · 2021
    Review
  6. Review
  7. Article
  8. Effects of Single Nucleotide Polymorphisms in HumanFrontiers in molecular neuroscience · 2019
    Article
  9. Article
  10. Structural basis and energy landscape for the CaProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  11. Physiological Roles and Therapeutic Potential of CaFrontiers in molecular neuroscience · 2018
    Review
  12. Article
  13. Review
  14. Understanding the conformational motions of RCK gating rings.The Journal of general physiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Pablo MirandaNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; pablo.mirandafernandez2@nih.gov.
Teresa GiraldezDepartamento de Ciencias Médicas Básicas, Instituto de Tecnologías Biomédicas y Centro de Investigaciones Biomédicas de Canarias, Universidad de La Laguna, 38071 La Laguna, Spain.
Miguel HolmgrenNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
National Institutes of Health · USUniversidad de La Laguna · ES

Funding

Structure and Function of Membrane ProteinsZIANS002993 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HOLMGREN, MIGUEL · 2009 to 2025
$24.0M
6 · The paper itself

Abstract

Large-conductance voltage- and calcium-activated K

Indexed as

Allosteric RegulationAmino Acid SequenceAnimalsBinding SitesCalciumCalcium-Binding ProteinsCationsCations, DivalentIon Channel GatingLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMembrane PotentialsOocytesPotassium Channels, Calcium-ActivatedProtein SubunitsXenopus laevisCalciumCalcium-Binding ProteinsCationsCations, DivalentLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsPotassium Channels, Calcium-ActivatedProtein Subunitsallosteric regulationdivalent ionsFRETSLO1 channel

Identifiers

PMID27872281
PMCPMC5150367
OpenAlexW2552595556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.