ArticleSchizophrenia bulletin2017
Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review on the Influences of Neurotoxicological Xenobiotic Compounds on Inhibitory Control.Frontiers in behavioral neuroscience · 2019Pooled it
- Psychogenic polydipsia in dogs - a review of pathogenesis, diagnosis and treatment.The Journal of small animal practice · 2026Review
- Sex differences in compulsive alcohol drinking phenotypes: implications for decision-making and social behavior in a preclinical model.Psychopharmacology · 2026Article
- Increased Neuroplasticity in Frontal Cortex to Reduce Compulsive Behavior: A Preclinical tDCS Study in Male Rats.Molecular neurobiology · 2025Article
- From compulsivity to compulsion: the neural basis of compulsive disorders.Nature reviews. Neuroscience · 2024Review
- Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats.Molecular neurobiology · 2023Article
- Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats.Behavioral and brain functions : BBF · 2023Article
- The development of compulsive coping behavior depends on dorsolateral striatum dopamine-dependent mechanisms.Molecular psychiatry · 2023Article
- Behavioral domains in compulsive rats: implications for understanding compulsive spectrum disorders.Frontiers in behavioral neuroscience · 2023Article
- Differential Neurobiological Markers in Phenotype-stratified Rats Modeling High or Low Vulnerability to Compulsive Behavior: A Narrative Review.Current neuropharmacology · 2023Review
- Increased Fear Memory and Glutamatergic Modulation in Compulsive Drinker Rats Selected by Schedule-Induced Polydipsia.Frontiers in behavioral neuroscience · 2019Article
- Do psychoactive drugs have a therapeutic role in compulsivity? Studies on schedule-induced polydipsia.Psychopharmacology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychogenic polydipsia, which is compulsive, non-regulatory fluid consumption, is present in 6%-20% of chronic psychiatric patients and frequently associated with the schizophrenia diagnosis. In the present study, we investigated the relation between schizophrenia-like symptoms and biomarkers with a compulsive drinking behavior phenotype in rats. Rats that were selected for low drinking vs high drinking behavior following schedule-induced polydipsia (SIP) were assessed in a latent inhibition (LI) paradigm using tone and electrical foot shock and in a spatial reversal learning task to evaluate behavioral inflexibility. We also analyzed the myelin basic protein in different brain areas of high drinker (HD) and low drinker (LD) rats. The HD rats, which were characterized by a compulsive drinking behavior on SIP, had a reduced level of LI effect and increased behavioral inflexibility in the spatial reversal learning task in comparison to the LD group. Moreover, HD rats showed less myelination in the center of the corpus callosum, striatum, and amygdala in comparison to LD rats. These findings strengthen the validity of HD rats that were selected by SIP as a possible phenotype of compulsive neuropsychiatric disorders, as evidenced by the existence of behaviors and biological markers that are related to schizophrenia and obsessive-compulsive disorder, including a reduced LI effect, behavioral inflexibility and reduced brain myelination. Future studies could contribute to the elucidation of the mechanisms underlying the compulsive phenotype of HD rats and its relation to vulnerability to schizophrenia.
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