ArticleSchizophrenia bulletin2017
Bipolar At-Risk Criteria: An Examination of Which Clinical Features Have Optimal Utility for Identifying Youth at Risk of Early Transition From Depression to Bipolar Disorders.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Distinguishing bipolar disorder from unipolar depression in general practice: A systematic review.The European journal of general practice · 2026Pooled it
- A systematic review and meta-analysis of sleep and circadian rhythms disturbances in individuals at high-risk of developing or with early onset of bipolar disorders.Neuroscience and biobehavioral reviews · 2022Pooled it
- "It felt very special, it felt customised to me"-A qualitative investigation of the experiences of participating in a clinical trial of CBT for young people at risk of bipolar disorder.Psychology and psychotherapy · 2021Trial
- Advancing the prediction of factors associated with bipolar disorder risk: utilizing early recognition tools and polygenic risk scores.International journal of bipolar disorders · 2025Article
- Article
- Bipolar At-Risk Criteria and Risk of Bipolar Disorder Over 10 or More Years.JAMA network open · 2023Article
- Bipolar Chronobiology in Men and Mice: A Narrative Review.Brain sciences · 2023Review
- Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.Bipolar disorders · 2022Review
- Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults.Translational psychiatry · 2021Article
- Adjuvant psychotherapy in early-stage bipolar disorder: study protocol for a randomized controlled trial.Trials · 2020Article
- The Continuum Between Temperament and Mental Illness as Dynamical Phases and Transitions.Frontiers in psychiatry · 2020Review
- Medical Diagnostic Tests: A Review of Test Anatomy, Phases, and Statistical Treatment of Data.Computational and mathematical methods in medicine · 2019Review
- Epidemiology and risk factors for bipolar disorder.Therapeutic advances in psychopharmacology · 2018Review
- [Psychotherapy for people with bipolar disorders : An overview of evidence-based procedures and new developments].Der Nervenarzt · 2018Review
- Identifying and treating the prodromal phases of bipolar disorder and schizophrenia.Current treatment options in psychiatry · 2018Article
- A Review of Matched-pairs Feature Selection Methods for Gene Expression Data Analysis.Computational and structural biotechnology journal · 2018Review
- Prodrome or risk syndrome: what's in a name?International journal of bipolar disorders · 2017Article
- Development and Validation of a Clinically Based Risk Calculator for the Transdiagnostic Prediction of Psychosis.JAMA psychiatry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 3 countries.
Funding
Abstract
Background: A clinical and research challenge is to identify which depressed youth are at risk of "early transition to bipolar disorders (ET-BD)." This 2-part study (1) examines the clinical utility of previously reported BD at-risk (BAR) criteria in differentiating ET-BD cases from unipolar depression (UP) controls; and (2) estimates the Number Needed to Screen (NNS) for research and general psychiatry settings. Methods: Fifty cases with reliably ascertained, ET-BD I and II cases were matched for gender and birth year with 50 UP controls who did not develop BD over 2 years. We estimated the clinical utility for finding true cases and screening out non-cases for selected risk factors and their NNS. Using a convenience sample (N = 80), we estimated the NNS when adjustments were made to account for data missing from clinical case notes. Results: Sub-threshold mania, cyclothymia, family history of BD, atypical depression symptoms and probable antidepressant-emergent elation, occurred significantly more frequently in ET-BD youth. Each of these "BAR-Depression" criteria demonstrated clinical utility for screening out non-cases. Only cyclothymia demonstrated good utility for case finding in research settings; sub-threshold mania showed moderate utility. In the convenience sample, the NNS for each criterion ranged from ~4 to 7. Conclusions: Cyclothymia showed the optimum profile for case finding, screening and NNS in research settings. However, its presence or absence was only reported in 50% of case notes. Future studies of ET-BD instruments should distinguish which criteria have clinical utility for case finding vs screening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.