Evidence map›Paper›PMID 27872208›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Blocking Virus Replication during Acute Murine Cytomegalovirus Infection Paradoxically Prolongs Antigen Presentation and Increases the CD8+ T Cell Response by Preventing Type I IFN-Dependent Depletion of Dendritic Cells.

Christopher P Loo, Christopher M Snyder, Ann B Hill

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Optimal CD8Immunology · 2021
    Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christopher P LooDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239; and.ORCID 0000-0002-5302-8774
Christopher M SnyderDepartment of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0003-1370-7198
Ann B HillDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239; and hillan@ohsu.edu.
Oregon Health & Science University · USThomas Jefferson University · US

Funding

INTERACTIONS AT THE MICROBE/HOST INTERFACET32AI007472 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LANDFEAR, SCOTT M · 1995 to 2019
$6.7M
The CD8 T cell response to murine cytomegalovirusR01AI047206 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HILL, ANN B · 2002 to 2015
$4.6M
Inflammation and T Lymphocyte ImmunoregulationT32AI078903 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HILL, ANN B · 2009 to 2013
$1.5M
Maintenance of the virus-specific T cell equillibrium in chronic MCMV infectionK22AI081866 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SNYDER, CHRISTOPHER M · 2010 to 2011
$270k
NIAID NIH HHS K22 AI081866NIAID NIH HHS R01 AI047206NIAID NIH HHS T32 AI007472NIAID NIH HHS T32 AI078903
6 · The paper itself

Abstract

Increasing amounts of pathogen replication usually lead to a proportionate increase in size and effector differentiation of the CD8

Indexed as

Virus ReplicationAdoptive TransferAnimalsAntigen PresentationCD8-Positive T-LymphocytesCell SeparationCross-PrimingDendritic CellsDisease Models, AnimalHerpesviridae InfectionsInterferon Type IMiceMuromegalovirusInterferon Type I

Identifiers

PMID27872208
PMCPMC5173475
OpenAlexW2553041776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.