ArticleThe Journal of biological chemistry2017
Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production.
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Interleukin-11 Signaling in Liver Disease: Mechanisms, Cellular Crosstalk, and Therapeutic Potential.Biomolecules · 2026Review
- Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges.Frontiers in immunology · 2024Review
- KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance.Cell reports · 2023Article
- Bone Allograft Acid Lysates Change the Genetic Signature of Gingival Fibroblasts.International journal of molecular sciences · 2023Article
- Overexpression of FRA1 (Cells · 2023Article
- Article
- Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.International journal of molecular sciences · 2022Article
- NRF2: KEAPing Tumors Protected.Cancer discovery · 2022Article
- Omega‑3 polyunsaturated fatty acids inhibit IL‑11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity.International journal of molecular medicine · 2021Article
- 1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.Chemical research in toxicology · 2021Article
- Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.Nature communications · 2021Article
- The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1β protein.Molecular biology reports · 2020Article
- Molecular mechanism and health effects of 1,2-Naphtoquinone.EXCLI journal · 2020Review
- IL-11 prevents IFN-γ-induced hepatocyte death through selective downregulation of IFN-γ/STAT1 signaling and ROS scavenging.PloS one · 2019Article
- Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study.International journal of molecular sciences · 2018Review
- The expression analysis of Fra-1 gene and IL-11 protein in Iranian patients with ulcerative colitis.BMC immunology · 2018Article
- Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a crucial role in protection of cells from electrophile-induced toxicity through up-regulating phase II detoxifying enzymes and phase III transporters. We previously reported that oxidative stress induces up-regulation of interleukin-11 (IL-11), a member of the IL-6 family that ameliorates acetaminophen-induced liver toxicity. However, a role for IL-11 in protection of cells from electrophile-induced toxicity remains unclear. Here we show that an environmental electrophile, 1,2-naphthoquinone (1,2-NQ), but not 15d-prostaglandin J
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