ArticleNeuroscience letters2017
Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks.
Article in Neuroscience letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring Localized Provoked Vulvodynia: Insights from Animal Model Research.International journal of molecular sciences · 2024Pooled it
- Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization.Frontiers in molecular neuroscience · 2022Pooled it
- Hypothalamic representation of aggressiveness across mouse strains.Nature communications · 2026Article
- Strain-Dependent Network Activity Differences Underlie Social Decision-Making in Male Mice.eNeuro · 2026Article
- Outbred mice as an appropriate model for evaluating the immunogenicity of vaccines against porcine circovirus 2.Open veterinary journal · 2026Article
- Dichotomous Regulation of Social Behaviors by Nucleus Accumbens Neurons in Female and Male Syrian Hamsters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Gene Expansion and Regulatory Rewiring Shape Sex-Biased Evolution of the Mouse Submandibular Gland Secretome.bioRxiv : the preprint server for biology · 2026Article
- Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humans.NPJ Parkinson's disease · 2026Article
- Prior Exercise Attenuates LPS-Induced Neuroinflammation, Dopaminergic Dysfunction, and Fatigue-like Behavior in Mice.ACS omega · 2025Article
- Sex-specific behavioral changes in middle-aged mice.Scientific reports · 2025Article
- Developing Mouse Models for Ovarian Tissue Transplantation and Xenotransplantation: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Investigating therapeutic efficacy of silymarin on intestinal and muscular phases of trichinellosis: an experimental study.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Neural mechanisms underlying strain preference behaviour and plasticity in mice.Scientific reports · 2025Article
- Abnormal response to chronic social defeat stress and fear extinction in a mouse model ofFrontiers in neuroscience · 2025Article
- Article
- A Multiparadigm Approach to Characterize Dominance Behaviors in CD1 and C57BL6 Male Mice.eNeuro · 2024Article
- Review
- An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome.Disease models & mechanisms · 2024Article
- Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia.Neurobiology of disease · 2024Article
- Beyond fur color: differences in socio-emotional behavior and the oxytocin system between male BL6 and CD1 mice in adolescence and adulthood.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Inbred mouse strains have been used preferentially for behavioral testing over outbred counterparts, even though outbred mice reflect the genetic diversity in the human population better. Here, we compare the sociability of widely available outbred CD1 mice with the commonly used inbred C57BL/6J (C57) mice in the one-chamber social interaction test and the three-chamber sociability test. In the one-chamber task, intra-strain pairs of juvenile, non-littermate, male CD1 or C57 mice display a series of social and aggressive behaviors. While CD1 and C57 pairs spend equal amount of time socializing, CD1 pairs spend significantly more time engaged in aggressive behaviors than C57 mice. In the three-chamber task, sociability of C57 mice was less dependent on acclimation paradigms than CD1 mice. Following acclimation to all three chambers, both groups of age-matched male mice spent more time in the chamber containing a stranger mouse than in the empty chamber, suggesting that CD1 mice are sociable like C57 mice. However, the observed power suggests that it is easier to achieve statistical significance with C57 than CD1 mice. Because the stranger mouse could be considered as a novel object, we assessed for a novelty effect by adding an object. CD1 mice spend more time in the chamber with a stranger mouse than that a novel object, suggesting that their preference is social in nature. Thus, outbred CD1 mice are as appropriate as inbred C57 mice for studying social behavior using either the single or the three-chamber test using a specific acclimation paradigm.
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