Evidence map›Paper›PMID 27871910›Full record

ArticleEuropean journal of pharmacology2017

Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt

Maria Camilla Cerlesi, Huiping Ding, Mark F Bird, Norikazu Kiguchi, Federica Ferrari, Davide Malfacini, Anna Rizzi, Chiara Ruzza, David G Lambert, Mei-Chuan Ko and 2 more

Open access · greenAbstract read
In one paragraph

Article in European journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Novel Mixed NOP/Opioid Receptor Peptide Agonists.Journal of medicinal chemistry · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Effects of NOP-Related Ligands in Nonhuman Primates.Handbook of experimental pharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Maria Camilla CerlesiSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Huiping DingDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Mark F BirdDepartment of Cardiovascular Sciences, University of Leicester, Division of Anaesthesia, Critical Care and Pain Management, Leicester Royal Infirmary, Leicester LE2 7LX. UK.
Norikazu KiguchiDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Federica FerrariSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Davide MalfaciniSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Anna RizziSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Chiara RuzzaSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
David G LambertDepartment of Cardiovascular Sciences, University of Leicester, Division of Anaesthesia, Critical Care and Pain Management, Leicester Royal Infirmary, Leicester LE2 7LX. UK.
Mei-Chuan KoDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Girolamo CaloSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Remo GuerriniDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, Italy.
University of Ferrara · ITWake Forest University · USLeicester Royal Infirmary · GB

Funding

Pharmacological Studies of NOP ReceptorsR01DA032568 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KO, MEI-CHUAN · 2012 to 2016
$1.8M
Evaluation in Primates of Cocaine Esterase for the Treatment of Cocaine ToxicityR01DA023213 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KO, MEI-CHUAN · 2008 to 2010
$1.5M
Behavioral Pharmacology of ItchR01AR059193 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KO, MEI-CHUAN · 2010 to 2013
$1.3M
Intrathecal Opioid-Induced PruritusR01DA013685 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KO, MEI-CHUAN · 2001 to 2003
$735k
A novel spinal analgesic with mixed MOP/NOP actions in primatesR21DA040104 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KO, MEI-CHUAN · 2015 to 2016
$426k
NIAMS NIH HHS R01 AR059193NIDA NIH HHS R01 DA013685NIDA NIH HHS R01 DA023213NIDA NIH HHS R01 DA032568NIDA NIH HHS R21 DA040104
6 · The paper itself

Abstract

An innovative chemical strategy named peptide welding technology (PWT) has been developed for the facile synthesis of tetrabranched peptides. [Dmt

Indexed as

AnimalsChemistry Techniques, SyntheticCHO CellsCricetinaeCricetulusFemaleHumansMacaca mulattaMaleNociceptin ReceptorOligopeptidesReceptors, OpioidRecombinant Proteins(Dmt(1))N-OFQ(1-13)-NH(2)Nociceptin ReceptorOligopeptidesReceptors, OpioidRecombinant ProteinsCalcium mobilizationMonkey spinal analgesiaNOP and opioid receptorsPWT2-[Dmt(1)]N/OFQ(1–13)Receptor bindingStimulation of [(35)S]GTPγS binding

Identifiers

PMID27871910
PMCPMC5183561
OpenAlexW2555930632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.