ArticleJournal of biomechanics2017
Streamline crossing: An essential mechanism for aerosol dispersion in the pulmonary acinus.
Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Lung-on-a-chip: From design principles to disease applications.Biomicrofluidics · 2025Review
- Particle Deposition in Large-Scale Human Tracheobronchial Airways Predicted by Single-Path Modelling.International journal of environmental research and public health · 2023Article
- Surface tension effects on flow dynamics and alveolar mechanics in the acinar region of human lung.Heliyon · 2022Article
- Microflows in two-generation alveolar cells at an acinar bifurcation.Biomicrofluidics · 2022Article
- Microparticle Transport and Sedimentation in a Rhythmically Expanding Alveolar Chip.Micromachines · 2022Article
- Recent advances in the understanding of alveolar flow.Biomicrofluidics · 2022Review
- Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics.Advanced drug delivery reviews · 2021Review
- Investigation on Microparticle Transport and Deposition Mechanics in Rhythmically Expanding Alveolar Chip.Micromachines · 2021Article
- Biomimetics of the pulmonary environmentBiomicrofluidics · 2018Article
- One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The dispersion of inhaled microparticles in the pulmonary acinus of the lungs is often attributed to the complex interplay between convective mixing, due to irreversible flows, and intrinsic particle motion (i.e. gravity and diffusion). However, the role of each mechanism, the exact nature of such interplay between them and their relative importance still remain unclear. To gain insight into these dispersive mechanisms, we track liquid-suspended microparticles and extract their effective diffusivities inside an anatomically-inspired microfluidic acinar model. Such results are then compared to experiments and numerical simulations in a straight channel. While alveoli of the proximal acinar generations exhibit convective mixing characteristics that lead to irreversible particle trajectories, this local effect is overshadowed by a more dominant dispersion mechanism across the ductal branching network that arises from small but significant streamline crossing due to intrinsic diffusional motion in the presence of high velocity gradients. We anticipate that for true airborne particles, which exhibit much higher intrinsic motion, streamline crossing would be even more significant.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.