ArticleBiological psychiatry2017
Induction and Blockade of Adolescent Cocaine-Induced Habits.
Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Suicide ideation and psychotropic recreational drug use by adolescents: a systematic review and meta-analysis.Sao Paulo medical journal = Revista paulista de medicina · 2024Pooled it
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- BDNF in ventrolateral orbitofrontal cortex to dorsolateral striatum circuit moderates alcohol consumption, seeking and relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Parallel neuronal structural plasticity with memory trace formation in the orbitofrontal cortex.Nature communications · 2025Article
- Article
- A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit.Progress in neurobiology · 2024Article
- Further proof on the role of accumbal nNOS in cocaine-seeking behavior in rats.Pharmacological reports : PR · 2024Article
- Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom.Neuroscience and biobehavioral reviews · 2023Review
- GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice.PNAS nexus · 2023Article
- A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory.Nature neuroscience · 2022Article
- The Effects of Poria cocos on Rho Signaling-Induced Regulation of Mobility and F-Actin Aggregation in MK-801-Treated B35 and C6 Cells.Behavioural neurology · 2022Article
- Article
- The stressed orbitofrontal cortex.Behavioral neuroscience · 2021Article
- Long-Term Cocaine Self-administration Produces Structural Brain Changes That Correlate With Altered Cognition.Biological psychiatry · 2021Article
- Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cocaine Elevates Calcium-Dependent Activator Protein for Secretion 2 in the Mouse Orbitofrontal Cortex.Developmental neuroscience · 2021Article
- Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal-directed action: A brief review.Journal of neuroscience research · 2020Review
- Repeated cocaine exposure during adolescence impairs recognition memory in early adulthood: A role for BDNF signaling in the perirhinal cortex.Developmental cognitive neuroscience · 2020Article
- Morphological Responses of Excitatory Prelimbic and Orbitofrontal Cortical Neurons to Excess Corticosterone in Adolescence and Acute Stress in Adulthood.Frontiers in neuroanatomy · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCocaine use during adolescence increases vulnerability to drug dependence and decreases the likelihood that individuals will seek treatment as adults. Understanding how early-life cocaine exposure influences decision-making processes in adulthood is thus critically important.
methodsAdolescent or adult mice were exposed to subchronic cocaine, then behavioral sensitivity to changes in the predictive relationship between actions and their consequences was tested. Dendritic spines on the principal pyramidal neurons of the orbitofrontal prefrontal cortex (oPFC) were also imaged and enumerated. To determine whether cytoskeletal regulatory systems in the oPFC influenced decision-making strategies, we then inhibited the activity of Abl family and Rho kinases as well as NR2B-containing N-methyl-D-aspartate receptors. We also attempted to block the reinstatement of cocaine seeking in cocaine self-administering mice.
resultsAdult mice with a history of subchronic cocaine exposure in adolescence engaged habit-based response strategies at the expense of goal-directed decision-making strategies and had fewer dendritic spines in the oPFC. Inhibition of the cytoskeletal regulatory Abl family kinases in the oPFC recapitulated these neurobehavioral deficiencies, whereas Rho kinase inhibition corrected response strategies. Additionally, the NR2B-selective N-methyl-D-aspartate receptor antagonists ifenprodil and CP-101,606 blocked cocaine-induced habits; this was dependent on Abl family signaling in the oPFC. Ifenprodil also mitigated cue-induced reinstatement of cocaine seeking in mice self-administering cocaine.
conclusionsWe suggest that adolescent cocaine exposure confers a bias toward habit-based behavior in adulthood via long-term cellular structural modifications in the oPFC. Treatments aimed at mitigating the durable consequences of early-life cocaine use may benefit from targeting cytoskeletal regulatory systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.