ArticleJournal of the American Academy of Child and Adolescent Psychiatry2016
Reduced Hemispheric Asymmetry of White Matter Microstructure in Autism Spectrum Disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- The effect of lateralization bias of pain on pain, anxiety and cognition in mice.Experimental brain research · 2025Article
- Lifespan Trajectories of Asymmetry in White Matter Tracts.bioRxiv : the preprint server for biology · 2025Article
- Altered white matter connectivity is linked to language abilities in children with autism spectrum disorder: An automated fiber quantification study.Frontiers in psychiatry · 2025Article
- Sex differences in brain functional specialization and interhemispheric cooperation among children with autism spectrum disorders.Scientific reports · 2024Article
- Perceptual Grouping in Autism Spectrum Disorder: An Exploratory Magnetoencephalography Study.Journal of autism and developmental disorders · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson's disease.Journal of neurology · 2023Article
- Changes in the volumes and asymmetry of subcortical structures in healthy individuals according to gender.Anatomical science international · 2023Article
- Sex differences, asymmetry, and age-related white matter development in infants and 5-year-olds as assessed with tract-based spatial statistics.Human brain mapping · 2023Article
- Asymmetry Matters: Diffusion Tensor Tractography of the Uncinate Fasciculus in Children with Verbal Memory Deficits.AJNR. American journal of neuroradiology · 2022Article
- Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy.Brain and behavior · 2022Article
- Mapping brain asymmetry in health and disease through the ENIGMA consortium.Human brain mapping · 2022Review
- Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization.Molecular psychiatry · 2021Article
- 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam.Journal of autism and developmental disorders · 2021Article
- Dichotic listening performance and interhemispheric integration after administration of hydrocortisone.Scientific reports · 2021Article
- The genetic architecture of structural left-right asymmetry of the human brain.Nature human behaviour · 2021Article
- Co-activation pattern alterations in autism spectrum disorder-A volume-wise hierarchical clustering fMRI study.Brain and behavior · 2021Article
- Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9-10 year old children.Neuropharmacology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveMany past studies have suggested atypical functional and anatomical hemispheric asymmetries in autism spectrum disorder (ASD). However, almost all of these have examined only language-related asymmetries. Here, we conduct a comprehensive investigation of microstructural asymmetries across a large number of fiber tracts in ASD.
methodWe used diffusion tensor imaging for a comprehensive investigation of anatomical white matter asymmetries across the entire white matter skeleton, using tract-based spatial statistics in 41 children and adolescents with ASD and a matched group of 44 typically developing (TD) participants.
resultsWe found significant asymmetries in the TD group, being rightward for fractional anisotropy and leftward for mean diffusivity (with concordant asymmetries for radial and axial diffusivity). These asymmetries were significantly reduced in the group with ASD: in whole brain analysis for fractional anisotropy, and in a region where several major association and projection tracts travel in close proximity within occipital white matter for mean diffusivity, axial diffusivity, and radial diffusivity. No correlations between global white matter asymmetry and age or socio-communicative abilities were detected.
conclusionOur findings in TD children and adolescents can be interpreted as reflecting different processing modes (more integrative in the right and more specialized in the left hemisphere). These asymmetries and the "division of labor" between hemispheres implied by them appear to be diminished in autism spectrum disorder.
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