Evidence map›Paper›PMID 27871640›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2016

Multidimensional Influences on Autism Symptom Measures: Implications for Use in Etiological Research.

Karoline Alexandra Havdahl, Vanessa Hus Bal, Marisela Huerta, Andrew Pickles, Anne-Siri Øyen, Camilla Stoltenberg, Catherine Lord, Somer L Bishop

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.

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  15. Mid-childhood autism sibling recurrence in infants with a family history of autism.Autism research : official journal of the International Society for Autism Research · 2024
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Karoline Alexandra HavdahlNorwegian Institute of Public Health and Lovisenberg Hospital, Oslo, Norway.
Vanessa Hus BalUniversity of California-San Francisco.
Marisela HuertaWeill Cornell Medical College, New York.
Andrew PicklesKing's College London, UK.
Anne-Siri ØyenNorwegian Institute of Public Health and Lovisenberg Hospital, Oslo, Norway.
Camilla StoltenbergNorwegian Institute of Public Health, Oslo, and the University of Bergen, Norway.
Catherine LordWeill Cornell Medical College, New York.
Somer L BishopUniversity of California-San Francisco. Electronic address: Somer.Bishop@ucsf.edu.
Norwegian Institute of Public Health · NOCornell University · USUniversity of California, San Francisco · USKing's College London · GB

Funding

Transitioning to Adulthood: A Prospective Longitudinal StudyR01HD081199 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2015 to 2019
$3.1M
Longitudinal Studies of Autism Spectrum Disorders: 2 to 23R01MH081873 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2008 to 2012
$2.7M
Development of a Brief Screener for Research in Autism Spectrum DisordersRC1MH089721 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONK, CHRISTOPHER STEPHEN · 2009 to 2010
$997k
2/2 Development of a Screening Interview for Research Studies of ASDR01HD065277 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI BISHOP, SOMER L. · 2009 to 2010
$737k
NICHD NIH HHS R01 HD065277NICHD NIH HHS R01 HD081199NIMH NIH HHS R01 MH081873NIMH NIH HHS RC1 MH089721
6 · The paper itself

Abstract

objectiveGrowing awareness that symptoms of autism spectrum disorder (ASD) transcend multiple diagnostic categories, and major advances in the identification of genetic syndromes associated with ASD, have led to widespread use of ASD symptom measures in etiologic studies of neurodevelopmental disorders. Insufficient consideration of potentially confounding factors such as cognitive ability or behavior problems can have important negative consequences in interpretation of findings, including erroneous estimation of associations between ASD and etiologic factors.

methodParticipants were 388 children 2 to 13 years old with diagnoses of ASD or another neurodevelopmental disorder without ASD. Receiver operating characteristics methods were used to assess the influence of IQ and emotional and behavioral problems on the discriminative ability of 3 widely used ASD symptom measures: the Social Responsiveness Scale (SRS), the Autism Diagnostic Interview-Revised (ADI-R), and the Autism Diagnostic Observation Schedule (ADOS).

resultsIQ influenced the discriminative thresholds of the SRS and ADI-R, and emotional and behavioral problems affected the discriminative thresholds of the SRS, ADI-R, and ADOS. This resulted in low specificity of ASD cutoffs on the SRS and ADI-R for children with intellectual disability without ASD (27-42%) and low specificity across all 3 instruments for children without ASD with increased emotional and behavioral problems (36-59%). Adjustment for these characteristics resulted in improved discriminative ability for all of the ASD measures.

conclusionThe findings indicate that scores on ASD symptom measures reflect far more than ASD symptoms. Valid interpretation of scores on these measures requires steps to account for the influences of IQ and emotional and behavioral problems.

Indexed as

AdolescentAutism Spectrum DisorderChildChild, PreschoolFemaleHumansMalePsychiatric Status Rating ScalesPsychometricsAutism Diagnostic Interview–RevisedAutism Diagnostic Observation Schedulediscriminative abilitymeasurementSocial Responsiveness Scale

Identifiers

PMID27871640
PMCPMC5131801
OpenAlexW2524395647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.