ArticleJournal of the American Academy of Child and Adolescent Psychiatry2016
Comparing Brain Morphometry Across Multiple Childhood Psychiatric Disorders.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature.European child & adolescent psychiatry · 2023Pooled it
- Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies.Journal of neurodevelopmental disorders · 2019Pooled it
- Beyond out-of-sample: robust and generalizable multivariate neuroanatomical patterns of psychiatric problems in youth.Molecular psychiatry · 2025Article
- Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Brain volumes, behavioral inhibition, and anxiety disorders in children: results from the adolescent brain cognitive development study.BMC psychiatry · 2024Article
- Greed personality trait links to negative psychopathology and underlying neural substrates.Social cognitive and affective neuroscience · 2023Article
- Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans.eLife · 2022Article
- Network-wise surface-based morphometric insight into the cortical neural circuitry underlying irritability in adolescents.Translational psychiatry · 2021Article
- Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability.Human brain mapping · 2021Article
- Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group.Translational psychiatry · 2021Article
- Bridging Anxiety and Depression: A Network Approach in Anxious Adolescents.Journal of affective disorders · 2021Article
- Parsing differences in amygdala volume among individuals with and without social and generalized anxiety disorders across the lifespan.Journal of psychiatric research · 2020Article
- Comorbid anxiety and irritability symptoms and their association with cognitive functioning in children with ADHD.Journal of abnormal child psychology · 2020Article
- Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study.Magnetic resonance imaging · 2020Article
- Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure.Biological psychiatry · 2020Article
- Exposure-Based Cognitive-Behavioral Therapy for Disruptive Mood Dysregulation Disorder: An Evidence-Based Case Study.Behavior therapy · 2020Article
- Article
- Accelerated cortical thinning within structural brain networks is associated with irritability in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Editorial: Linking Emotional and Behavioral Dysregulation in Adolescents to Regulatory Cortex.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
objectiveIn both children and adults, psychiatric illness is associated with structural brain alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray matter volume (GMV) in healthy volunteers (HVs) to one psychiatric group. We compared GMV among youth with anxiety disorders, bipolar disorder (BD), disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), and HVs.
method3-Tesla T1-weighted magnetic resonance imaging scans were acquired in 184 youths (39 anxious, 20 BD, 52 DMDD, 20 ADHD, and 53 HV). Voxel-based morphometry analyses were conducted. One-way analysis of variance tested GMV differences with whole-brain familywise error (p < .05) correction; secondary, exploratory whole-brain analyses used a threshold of p < .001, ≥200 voxels. Given recent frameworks advocating dimensional approaches in psychopathology research, we also tested GMV associations with continuous anxiety, irritability, and inattention symptoms.
resultsSpecificity emerged in the left dorsolateral PFC (dlPFC), which differed among youth with BD, anxiety, and HVs; GMV was increased in youth with anxiety, but decreased in BD, relative to HVs. Secondary analyses revealed BD-specific GMV decreases in the right lateral PFC, right dlPFC, and dorsomedial PFC, and also anxiety-specific GMV increases in the left dlPFC, right ventrolateral PFC, frontal pole, and right parahippocampal gyrus/lingual gyrus. Both BD and DMDD showed decreased GMV relative to HVs in the right dlPFC/superior frontal gyrus. GMV was not associated with dimensional measures of anxiety, irritability, or ADHD symptoms.
conclusionBoth disorder-specific and shared GMV differences manifest in pediatric psychopathology. Some differences were specific to anxiety disorders, others specific to BD, and others shared between BD and DMDD. Further developmental research might map commonalities and differences of structure and function in diverse pediatric psychopathologies.
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