ArticleAnnals of the rheumatic diseases1989
HLA-A, B antigens and alpha 1-antitrypsin phenotypes in nodal generalised osteoarthritis and erosive osteoarthritis.
Article in Annals of the rheumatic diseases, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.Annals of the rheumatic diseases · 2023Pooled it
- Erosive hand osteoarthritis: latest findings and outlook.Nature reviews. Rheumatology · 2022 · on this mapReview
- Familial Clustering of Erosive Hand Osteoarthritis in a Large Statewide Cohort.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis.International journal of molecular sciences · 2017Review
- Erosive osteoarthritis: A systematic analysis of definitions used in the literature.Seminars in arthritis and rheumatism · 2017Review
- Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading.International journal of rheumatology · 2016Article
- Joint and bone assessment in hand osteoarthritis.Clinical rheumatology · 2014Review
- Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women.PloS one · 2012Article
- Hand osteoarthritis--a heterogeneous disorder.Nature reviews. Rheumatology · 2011Review
- Erosive osteoarthritis: a current review of a clinical challenge.Clinical rheumatology · 2010Review
- Article
- Genetics in osteoarthritis.Current genomics · 2008Article
- The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes.Rheumatology international · 2005Article
- HLA class II is associated with distal interphalangeal osteoarthritis.Annals of the rheumatic diseases · 2003Article
- Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q.American journal of human genetics · 1999Article
- Genetics of osteoarthritis.Annals of the rheumatic diseases · 1996Review
- The genetics of osteoarthritis.Journal of clinical pathology · 1996Article
- Association of two loci on chromosome 2q with nodal osteoarthritis.Annals of the rheumatic diseases · 1996Article
- Review
- Genetic aspects of familial osteoarthritis.Annals of the rheumatic diseases · 1994Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HLA-A, B and alpha 1-antitrypsin phenotypes were studied in 90 unrelated patients with established nodal generalised osteoarthritis (OA). Compared with standard reference populations, independently increased frequency of the HLA-A1B8 and MZ alpha 1-antitrypsin phenotypes were observed (27% v 11.5%, relative risk 2.79, and 12% v 3.6%, relative risk 3.73 respectively). These associations related to developed of nodal generalised OA rather than to severity as judged by the summated radiographic scores for hand OA. Ten patients had marked subchondral radiographic erosions and were further classified as erosive OA; these patients had an increased frequency of the MS alpha 1-antitrypsin phenotype (30% v 9%) and higher radiographic OA scores corrected for presence of erosions. This first report of two independent genetic markers in nodal generalised OA is of interest in relation to the increasingly recognised inflammatory component of the osteoarthritis process.
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