ArticleBMC nephrology2016
Familial aggregation of albuminuria and arterial hypertension in an Aboriginal Australian community and the contribution of variants in ACE and TP53.
Article in BMC nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Pooled it
- Novel genetic markers for chronic kidney disease in a geographically isolated population of Indigenous Australians: Individual and multiple phenotype genome-wide association study.Genome medicine · 2024Article
- Sociodemographic determinants of chronic kidney disease in Indigenous children.Pediatric nephrology (Berlin, Germany) · 2022Review
- Birthweight and the Prevalence, Progression, and Incidence of CKD in a Multideterminant Model in a High-Risk Australian Aboriginal Community.Kidney international reports · 2021Article
- Analysis of theFrontiers in genetics · 2020Article
- Programming of Renal Development and Chronic Disease in Adult Life.Frontiers in physiology · 2020Review
- Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.Nature communications · 2019Article
- New Genetic Loci Associated With Chronic Kidney Disease in an Indigenous Australian Population.Frontiers in genetics · 2019Article
- An expanded nationwide view of chronic kidney disease in Aboriginal Australians.Nephrology (Carlton, Vic.) · 2016Review
- Kidney disease in Aboriginal Australians: a perspective from the Northern Territory.Clinical kidney journal · 2014Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAboriginal Australians are at high risk of cardiovascular, metabolic and renal diseases, resulting in a marked reduction in life expectancy when compared to the rest of the Australian population. This is partly due to recognized environmental and lifestyle risk factors, but a contribution of genetic susceptibility is also likely.
methodsUsing results from a comprehensive survey of one community (N = 1350 examined individuals), we have tested for familial aggregation of plasma glucose, arterial blood pressure, albuminuria (measured as urinary albumin to creatinine ratio, UACR) and estimated glomerular filtration rate (eGFR), and quantified the contribution of variation at four candidate genes (ACE; TP53; ENOS3; MTHFR).
resultsIn the subsample of 357 individuals with complete genotype and phenotype data we showed that both UACR (h
conclusionsWhile the effects of the ACE insertion-deletion on risk of renal disease (especially in the setting of diabetes) are well recognized, this is only the second study to implicate p53 genotype as a risk factor for albuminuria - the other being an earlier study we performed in a different Aboriginal community (McDonald et al., J Am Soc Nephrol 13: 677-83, 2002). We conclude that there are significant genetic contributions to the high prevalence of chronic diseases observed in this population.
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Registered trials
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