Evidence map›Paper›PMID 27871197›Full record

ReviewExpert review of medical devices2017

Left ventricular assist device-induced reverse remodeling: it's not just about myocardial recovery.

Karolina K Marinescu, Nir Uriel, Douglas L Mann, Daniel Burkhoff

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of medical devices, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Myocardial Recovery.Diagnostics (Basel, Switzerland) · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Myofibrillolysis and fibrosis predicts myocardial insufficiency.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2019
    Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Karolina K Marinescua Department of Medicine, Division of Cardiology, Advanced Heart Failure , Rush University Medical Center , Chicago , IL , USA.
Nir Urielb Department of Medicine, Division of Cardiology , University of Chicago , Chicago , IL , USA.
Douglas L Mannc Department of Medicine, Division of Cardiology , Washington University School of Medicine/Barnes Jewish Hospital , St. Louis , MO , USA.
Daniel Burkhoffd Department of Medicine, Division of Cardiology , Columbia University Medical Center/New York-Presbyterian Hospital , New York , NY , USA.
Barnes-Jewish Hospital · USColumbia University Irving Medical Center · USRush University Medical Center · USUniversity of Chicago · US

Funding

CYTOPROTECTIVE EFFECTS OF INFLAMMATION MEDIATED MEMBRANE REPAIRR01HL111094 · NHLBI · WASHINGTON UNIVERSITY · PI MANN, DOUGLAS L · 2012 to 2016
$1.9M
CAUSE AND CONSEQUENCE OF TNF OVEREXPRESSION IN THE HEARTR01HL058081 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MANN, DOUGLAS LOWELL · 1998 to 2007
$1.4M
NHLBI NIH HHS R01 HL058081NHLBI NIH HHS R01 HL111094
6 · The paper itself

Abstract

introductionThe abnormal structure, function and molecular makeup of dilated cardiomyopathic hearts can be partially normalized in patients supported by a left ventricular assist device (LVAD), a process called reverse remodeling. This leads to recovery of function in many patients, though the rate of full recovery is low and in many cases is temporary, leading to the concept of heart failure remission, rather than recovery. Areas covered: We summarize data indicative of ventricular reverse remodeling, recovery and remission during LVAD support. These terms were used in searches performed in Pubmed. Duplication of topics covered in depth in prior review articles were avoided. Expert commentary: Although most patients undergoing mechanical circulatory support (MCS) show a significant degree of reverse remodeling, very few exhibit sufficiently improved function to justify device explantation, and many from whom LVADs have been explanted have relapsed back to the original heart failure phenotype. Future research has the potential to clarify the ideal combination of pharmacological, cell, gene, and mechanical therapies that would maximize recovery of function which has the potential to improve exercise tolerance of patients while on support, and to achieve a higher degree of myocardial recovery that is more likely to persist after device removal.

Indexed as

Heart-Assist DevicesVentricular RemodelingHumansMyocardiumRemission Inductionexercise toleranceextracellular matrixheart assist deviceHeart failureinflammationmicro-RNAsmyocardial remissionsympathetic activation

Identifiers

PMID27871197
PMCPMC5541390
OpenAlexW2556857984

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.