ArticleNature cell biology2017
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 115 citations in OpenAlex.
- Lineage tracing from cellular heritage to disease destiny.Nature genetics · 2026Review
- Charting single-cell lineages with synthetic and natural barcodes.Nature reviews. Genetics · 2026Review
- High-resolution, noninvasive single-cell lineage tracing in mice and humans based on DNA methylation epimutations.Nature methods · 2025Article
- Hematopoietic Stem Cell Fates and the Cellular Hierarchy of Mammalian Hematopoiesis: from Transplantation Models to New Insights from in Situ Analyses.Stem cell reviews and reports · 2025Review
- Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies.Stem cell research & therapy · 2024Review
- Dynamics of a diffusive model for cancer stem cells with time delay in microRNA-differentiated cancer cell interactions and radiotherapy effects.Scientific reports · 2024Article
- Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium.Nature cell biology · 2023Article
- Hematopoietic heterogeneity starts at the hemogenic endothelium.Cell research · 2023Article
- Learning from Zebrafish Hematopoiesis.Advances in experimental medicine and biology · 2023Review
- Hematopoietic Stem and Progenitor Cell Identification and Transplantation in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies.Stem cell reviews and reports · 2021Review
- Advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation.Stem cells translational medicine · 2021Review
- Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies.Frontiers in immunology · 2021Review
- Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation.Stem cell research & therapy · 2020Article
- Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation.Frontiers in immunology · 2020Review
- Blood making: learning what to put into the dish.F1000Research · 2020Review
- CRISPR takes genetic screens forward.Lab animal · 2020Article
- Unravelling cellular relationships during development and regeneration using genetic lineage tracing.Nature reviews. Molecular cell biology · 2019Review
- Development of anFuture science OA · 2019Article
- Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish.Blood advances · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 3 countries.
Jonathan HenningerStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Buyung SantosoSection of Cell and Developmental Biology, University of California at San Diego, La Jolla, California 92093, USA.
Stefan HansBiotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47-49, 01307 Dresden, Germany.
Ellen DurandStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jessica MooreStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Christian MosimannInstitute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland.ORCID http://orcid.org/0000-0002-0749-2576
Michael BrandBiotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47-49, 01307 Dresden, Germany.
David TraverSection of Cell and Developmental Biology, University of California at San Diego, La Jolla, California 92093, USA.
Leonard ZonStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Boston Children's Hospital · USTechnische Universität Dresden · DEUniversity of California San Diego · USUniversity of Zurich · CH
Funding
TRANSCRIPTION FACTOR GATA-1 IN TERMINAL ERYTHROID DEVELOPMENTP01HL032262 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI YIEN, YVETTE Y · 1985 to 2021
$38.9MCORE--ZEBRAFISHP30DK049216 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI ZHOU, YI · 1999 to 2015
$14.3MCustomized stem cells for clinical application in blood disordersR24DK092760 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2011 to 2018
$10.7MHuman Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood DiseasesU01HL100001 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, ORKIN, STUART H · 2009 to 2015
$8.9MStem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3MMolecular and functional dissection of zebrafish hematopoietic stem cell nicheR01DK074482 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TRAVER, DAVID · 2006 to 2024
$6.5MProject-002U54DK110805 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ORKIN, STUART H, ZON, LEONARD IRA · 2016 to 2020
$5.9MEMBRYONIC HEMATOPOIESISR01HL048801 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 1992 to 2016
$5.7MCOMPARATIVE APPROACH TO GLOBIN REGULATION/THALASSEMIAR01DK053298 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 1998 to 2012
$3.9MIdentifying factors that promote clonal dominance in zebrafish hematopoiesisF31HL126338 · NHLBI · HARVARD MEDICAL SCHOOL · PI HENNINGER, JONATHAN EDWARD · 2015 to 2017
$98kHoward Hughes Medical InstituteNHLBI NIH HHS F31 HL126338NHLBI NIH HHS P01 HL032262NHLBI NIH HHS R01 HL048801NHLBI NIH HHS U01 HL100001NHLBI NIH HHS U01 HL134812NIDDK NIH HHS P30 DK049216NIDDK NIH HHS R01 DK053298NIDDK NIH HHS R01 DK074482NIDDK NIH HHS R24 DK092760NIDDK NIH HHS U54 DK110805
Abstract
Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal analysis of HSCs in zebrafish to quantify developing HSCs. Targeting creER
Indexed as
Cell LineageEmbryonic DevelopmentAgingAnimalsBlood VesselsBone Marrow CellsBone Marrow TransplantationCell CountClone CellsEmbryo, NonmammalianErythroid CellsGranulocytesHematopoiesisHematopoietic Stem CellsLasersPlatelet Membrane Glycoprotein IIbPlatelet Membrane Glycoprotein IIb
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.