ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2017
Impact of Extent of Resection on Local Control and Survival in Patients From the COG A3973 Study With High-Risk Neuroblastoma.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 169 citations in OpenAlex.
- Roles of Surgery in the Treatment of Patients With High-Risk Neuroblastoma in the Children Oncology Group Study: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- A phase IIa trial of molecular radiotherapy with 177-lutetium DOTATATE in children with primary refractory or relapsed high-risk neuroblastoma.European journal of nuclear medicine and molecular imaging · 2020Trial
- Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG).International journal of clinical oncology · 2018Trial
- Review
- Inter-reader agreement and diagnostic accuracy of early postoperative magnetic resonance imaging for detecting macroscopic residual disease in neuroblastic tumors.Pediatric radiology · 2026Article
- Electroporation as a strategy to improve the efficacy of chemotherapy in neuroblastoma: an in vitro study.Radiology and oncology · 2026Article
- Image defined risk factor(s) and outcomes for abdominal neuroblastoma: a surgical perspective from a Thailand National Cancer Centre.Pediatric surgery international · 2026Article
- Cadaveric analysis of a safe trail for surgical exposure of the anterior cervico-thoracic junction.BMC surgery · 2026Article
- Article
- Diagnosis and management of neuroblastoma in children.World journal of pediatric surgery · 2026Review
- Primary Renal Neuroblastoma: A Case Report and Review of the Literature.Current pediatric reviews · 2026Review
- Fluorescence-Guided Surgery in Pediatric Oncology: Current Practice and Future Directions.Cancers · 2025Review
- Expanding the therapeutic horizon ofNagoya journal of medical science · 2025Review
- Cold Atmospheric Plasma Selectively Targets Neuroblastoma: Mechanistic Insights and In Vivo Validation.Cancers · 2025Article
- Vascular encasement image defined risk factors independently predict surgical complications in neuroblastoma.ANZ journal of surgery · 2025Article
- Hypofractionated Palliative Radiotherapy for Relapsed and Refractory High-Risk Neuroblastoma.Current oncology (Toronto, Ont.) · 2025Article
- Detection properties of indium-111 and IRDye800CW for intraoperative molecular imaging use across tissue phantom models.Journal of biomedical optics · 2025Article
- Characteristics, treatments, and outcomes of adolescents and adults with neuroblastoma: a retrospective study in China.Therapeutic advances in medical oncology · 2025Article
- Dual-labeled anti-GD2 targeted probe for intraoperative molecular imaging of neuroblastoma.Journal of translational medicine · 2024Article
- A subset of image-defined risk factors predict completeness of resection in children with high-risk neuroblastoma: An international multicenter study.Pediatric blood & cancer · 2024Article
3 more citing papers are in PubMed but not listed here.
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10 authors at 1 institution in 1 country.
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Abstract
Purpose This analysis of patients in the Children's Oncology Group A3973 study evaluated the impact of extent of primary tumor resection on local progression and survival and assessed concordance between clinical and central imaging review-based assessments of resection extent. Patients and Methods The analytic cohort (n = 220) included patients who had both central surgery review and resection of the primary tumor site. For this analysis, resection categories of < 90% and ≥ 90% were used, with data on resection extent derived from operating surgeons' assessments (all patients), as well as blinded central imaging review of computed tomography scans for a subset of 84 patients; assessment results were compared for concordance. Treatment outcomes included event-free survival (EFS), overall survival (OS), and cumulative incidence of local progression (CILP). Results Surgeon-assessed extent of resection was ≥ 90% in 154 (70%) patients and < 90% in 66 (30%). Five-year EFS, OS, and CILP (± SE) were 43.5% ± 3.7%, 54.9% ± 3.7%, and 11.9% ± 2.2%, respectively. EFS was higher with ≥ 90% resection (45.9% ± 4.3%) than with < 90% resection (37.9% ± 7.2%; P = .04). Lower CILP ( P = .01) was associated with ≥ 90% resection (8.5% ± 2.3%) compared with < 90% resection (19.8% ± 5.0%). On multivariable analysis, ≥ 90% resection was associated with longer EFS after adjustment for MYCN amplification or diploidy but had no significant effect on OS. Concordance between surgeons' assessments of resection extent and central image-guided review was low, with agreement of 63% (< 90% v ≥ 90%; simple κ = -0.0301). Conclusion Despite discordance between clinical assessment of resection extent and assessment via central imaging review, a surgeon-assessed resection extent ≥ 90% was associated with significantly better EFS and lower CILP. Improving OS, however, remains a challenge in this disease. These findings support continued attempts at ≥ 90% resection of the primary tumor in high-risk neuroblastoma.
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