ReviewJournal of neuroscience research2017
Sex differences in the immune response to experimental stroke: Implications for translational research.
Review in Journal of neuroscience research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Exosomes on Neurological Function Recovery for Ischemic Stroke in Pre-clinical Studies: A Meta-analysis.Frontiers in cellular neuroscience · 2020Pooled it
- Beyond the usual suspects: rethinking post-stroke immunosuppression.Frontiers in immunology · 2026Review
- Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial.Circulation research · 2024Article
- Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice.Experimental neurology · 2024Article
- Antioxidant and Anti-Inflammatory Effects of Garlic in Ischemic Stroke: Proposal of a New Mechanism of Protection through Regulation of Neuroplasticity.Antioxidants (Basel, Switzerland) · 2023Review
- X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals.Translational stroke research · 2023Article
- Sex Differences in Immune Cell Infiltration and Hematuria in SCI-Induced Hemorrhagic Cystitis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- Immune regulation based on sex differences in ischemic stroke pathology.Frontiers in immunology · 2023Review
- Descriptive analysis of post-stroke patients in a neurological physical therapy unit.Frontiers in neurology · 2023Article
- Sex-Specific Immune Responses in Stroke.Stroke · 2022Review
- Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes.Frontiers in aging neuroscience · 2022Article
- Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury.Cell reports · 2021Article
- Effect of sex differences on prognosis of intravenous thrombolysis: data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China).Stroke and vascular neurology · 2021Article
- Filtered air intervention reduces inflammation and hypothalamus-pituitary-adrenal axis activation in adult male and female rats after PM 2.5 exposure.Environmental science and pollution research international · 2020Article
- Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice.Frontiers in aging neuroscience · 2020Article
- Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells.Journal of neurotrauma · 2019Article
- Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion.Journal of neuroinflammation · 2018Article
- Sex- and Development-Dependent Responses of Rat Microglia to Pro- and Anti-inflammatory Stimulation.Frontiers in cellular neuroscience · 2018Article
- Sex differences in regulatory cells in experimental stroke.Cellular immunology · 2017Article
- Microglial Function across the Spectrum of Age and Gender.International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than males and, therefore, have a worse stroke outcome. There are also major differences in how the sexes respond to stroke at the cellular level. Immune response is a critical factor in determining the progress of neurodegeneration after stroke and is fundamentally different for males and females. Additionally, females respond to stroke therapies differently from males, yet they are often left out of the basic research that is focused on developing those therapies. With a resounding failure to translate stroke therapies from the bench to the bedside, it is clearer than ever that inclusion of both sexes in stroke studies is essential for future clinical success. This Mini-Review examines sex differences in the immune response to experimental stroke and its implications for therapy development. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.