Evidence map›Paper›PMID 27870443›Full record

ReviewJournal of neuroscience research2017

Sex differences in depression during pregnancy and the postpartum period.

Inger Sundström Poromaa, Erika Comasco, Marios K Georgakis, Alkistis Skalkidou

2 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in Journal of neuroscience research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05282277 phase4recruitingnot on this mapstarted 2022, after this paper: background citation

Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2026Enrolled103ConditionsDepression, Psychosis, AnhedoniaArmsTransdermal Estradiol, Micronized Progesterone, Matching Placebo Patch, Raclopride C11
NCT07517549 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effect Of Sexual Counseling Based On the Extended Plissit Model On Sexual Function, Marital Adjustment, Sexual Quality Of Life, Depression, Anxiety, And Stress During Pregnancy And Postpartum

TypeinterventionalSponsorOrdu UniversityRan2026 to 2026Enrolled70ConditionsSexuality, Depression, Pregnancy RelatedArmssexuality health education group
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  7. The dyadic associations among self-efficacy, dyadic coping, and health-related quality of life between high-risk pregnant women and spouses: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Article
  8. Article
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  10. Review
  11. Article
  12. Review
  13. Pregnancy Care during the COVID-19 Pandemic in Germany: A Public Health Lens.International journal of environmental research and public health · 2023
    Review
  14. Article
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  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Inger Sundström PoromaaDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Erika ComascoDepartment of Neuroscience, Uppsala University, Uppsala, Sweden.
Marios K GeorgakisDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Alkistis SkalkidouDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Women have a lifetime risk of major depression double that of men but only during their reproductive years. This sex difference has been attributed partially to activational effects of female sex steroids and also to the burdens of pregnancy, childbirth, and parenting. Men, in contrast, have a reproductive period difficult to delineate, and research on the mental health of men has rarely considered the effects of fatherhood. However, the couple goes through a number of potentially stressing events during the reproductive period, and both mothers and fathers are at risk of developing peripartum depression. This Review discusses the literature on maternal and paternal depression and the endocrine changes that may predispose a person to depression at this stage of life, with specific focus on the hypothalamus-pituitary axis, oxytocin, and testosterone levels in men. Important findings on sex differences in the neural correlates of maternal and paternal behavior have emerged, highlighting the relevance of the emotional brain in mothers and the sociocognitive brain in fathers and pointing toward the presence of a common parents' brain. Additionally, sex differences in neurogenesis and brain plasticity are described in relation to peripartum depression. © 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc.

Indexed as

Sex CharacteristicsDepressionDepression, PostpartumFemaleHumansMalePregnancycortisolneuroimagingoxytocinperipartum depressionsextestosterone

Identifiers

PMID27870443
PMCPMC5129485
OpenAlexW2553998144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.