ReviewJournal of neuroscience research2017
Sex-based differences in brain alterations across chronic pain conditions.
Review in Journal of neuroscience research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis.Scientific reports · 2023Pooled it
- Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Age as a Mediator of tDCS Effects on Pain: An Integrative Systematic Review and Meta-Analysis.Frontiers in human neuroscience · 2020Pooled it
- Pooled it
- Cortical excitability and analgesic effects of multisite transcranial direct current stimulation targeting the motor cortex and cerebellum in fibromyalgia.Scientific reports · 2025Trial
- Home-Based Transcranial Direct Current Stimulation vs Placebo for Fibromyalgia: A Randomized Clinical Trial.JAMA network open · 2025Trial
- The Hypnotic Analgesia Suggestion Mitigated the Effect of the Transcranial Direct Current Stimulation on the Descending Pain Modulatory System: A Proof of Concept Study.Journal of pain research · 2020Trial
- Review
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Psychological Factors Predict Response to a Low Fermentable Oligo-, di-, Monosaccharide and Polyol Dietary Intervention in Irritable Bowel Syndrome: A Prospective Cohort Study.United European gastroenterology journal · 2026Article
- Modulation of Brain Activity in Patients with Acute Non-Specific Low Back Pain by Wentong Guan Therapy: A Functional Near-Infrared Spectroscopy Study.Journal of pain research · 2026Article
- Convergent structural brain alterations in chronic pain: a multi-metric individual participant data meta-analysis.Brain communications · 2026Article
- Sex-related associations between psychoemotional factors and health-related quality of life in patients with chronic low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Applicability of the theory of pain-sensorimotor interactions to orofacial pain and sensorimotor behavior, and implications for orofacial pain research and management.Journal of oral & facial pain and headache · 2025Review
- The emergence of sex differences in primary pain during adolescence: a conceptual developmentally-oriented biopsychosocial model and opportunities for further investigation.BMC pediatrics · 2025Review
- Article
- Real-World Prescribing Patterns and Treatment Continuation of Amitriptyline Monotherapy and Aripiprazole Augmentation for Medically Unexplained Oral Symptoms/Syndromes in Japan.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Sex-based associations between neighborhood disadvantage and brain-gut alterations in individuals with irritable bowel syndrome.Biology of sex differences · 2025Article
- Somatosensory and prefrontal cortex activity relates to emotional outcomes and hair cortisol concentration in chronic postsurgical pain.Scientific reports · 2025Article
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Common brain mechanisms are thought to play a significant role across a multitude of chronic pain syndromes. In addition, there is strong evidence for the existence of sex differences in the prevalence of chronic pain and in the neurobiology of pain. Thus, it is important to consider sex when developing general principals of pain neurobiology. The goal of the current Mini-Review is to evaluate what is known about sex-specific brain alterations across multiple chronic pain populations. A total of 15 sex difference and 143 single-sex articles were identified from among 412 chronic pain neuroimaging articles. Results from sex difference studies indicate more prominent primary sensorimotor structural and functional alterations in female chronic pain patients compared with male chronic pain patients: differences in the nature and degree of insula alterations, with greater insula reactivity in male patients; differences in the degree of anterior cingulate structural alterations; and differences in emotional-arousal reactivity. Qualitative comparisons of male-specific and female-specific studies appear to be consistent with the results from sex difference studies. Given these differences, mixed-sex studies of chronic pain risk creating biased data or missing important information and single-sex studies have limited generalizability. The advent of large-scale neuroimaging databases will likely aid in building a more comprehensive understanding of sex differences and commonalities in brain mechanisms underlying chronic pain. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.