ReviewJournal of neuroscience research2017
Sexual modulation of sex-shared neurons and circuits in Caenorhabditis elegans.
Review in Journal of neuroscience research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Stress induced hyperphagia iniScience · 2026Article
- Neuronal Nrf/SKN-1B controls a sexually dimorphic neuroendocrine pathway for C. elegans exploratory behaviour.PLoS genetics · 2026Article
- Sexual dimorphism in the nervous system: Three principles from the nematode C.elegans.Current opinion in neurobiology · 2026Review
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Male-specific behavioral and transcriptomic changes in agingiScience · 2024Article
- C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues.Current biology : CB · 2024Article
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- Neuropeptide signalling shapes feeding and reproductive behaviours in maleLife science alliance · 2022Article
- Sex differences in decision-making: Identifying multisensory behavioral differences in males and hermaphrodites.microPublication biology · 2022Article
- Visualizing the organization and differentiation of the male-specific nervous system of C. elegans.Development (Cambridge, England) · 2021Article
- Wired for insight-recent advances in Caenorhabditis elegans neural circuits.Current opinion in neurobiology · 2021Review
- Sexually Dimorphic Neurotransmitter Release at the Neuromuscular Junction in AdultFrontiers in molecular neuroscience · 2021Article
- Dynamic, Non-binary Specification of Sexual State in the C. elegans Nervous System.Current biology : CB · 2020Article
- C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization.Current biology : CB · 2020Article
- Article
- The MakorineLife · 2019Article
- A matter of timing.eLife · 2019Article
- Article
- Molecular mechanisms underlying sexual differentiation of the nervous system.Current opinion in neurobiology · 2018Review
- A Single-Neuron Chemosensory Switch Determines the Valence of a Sexually Dimorphic Sensory Behavior.Current biology : CB · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Studies using the nematode C. elegans have provided unique insights into the development and function of sex differences in the nervous system. Enabled by the relative simplicity of this species, comprehensive studies have solved the complete cellular neuroanatomy of both sexes as well as the complete neural connectomes of the entire adult hermaphrodite and the adult male tail. This work, together with detailed behavioral studies, has revealed three aspects of sex differences in the nervous system: sex-specific neurons and circuits; circuits with sexually dimorphic synaptic connectivity; and sex differences in the physiology and functions of shared neurons and circuits. At all of these levels, biological sex influences neural development and function through the activity of a well-defined genetic hierarchy that acts throughout the body to translate chromosomal sex into the state of a master autosomal regulator of sexual differentiation, the transcription factor TRA-1A. This Review focuses on the role of genetic sex in implementing sex differences in shared neurons and circuits, with an emphasis on linking the sexual modulation of specific neural properties to the specification and optimization of sexually divergent and dimorphic behaviors. An important and unexpected finding from these studies is that chemosensory neurons are a primary focus of sexual modulation, with genetic sex adaptively shaping chemosensory repertoire to guide behavioral choice. Importantly, hormone-independent functions of genetic sex are the principal drivers of all of these sex differences, making nematodes an excellent model for understanding similar but poorly understood mechanisms that likely act throughout the animal kingdom. © 2016 Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.